methyl E-3-[3'-(adamantan-1-yl)-2'-methyl-4'-hydroxybiphenyl-4-yl]acrylate

Base Information

Chemical Name:methyl E-3-[3'-(adamantan-1-yl)-2'-methyl-4'-hydroxybiphenyl-4-yl]acrylate
CAS No.:862650-94-0
Molecular Formula:C₂₇H₃₀O₃
Molecular Weight:402.533
Hs Code.:

Synonyms:methyl E-3-[3'-(adamantan-1-yl)-2'-methyl-4'-hydroxybiphenyl-4-yl]acrylate

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Chemical Property of methyl E-3-[3'-(adamantan-1-yl)-2'-methyl-4'-hydroxybiphenyl-4-yl]acrylate

Chemical Property:

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Technology Process of methyl E-3-[3'-(adamantan-1-yl)-2'-methyl-4'-hydroxybiphenyl-4-yl]acrylate

There total 4 articles about methyl E-3-[3'-(adamantan-1-yl)-2'-methyl-4'-hydroxybiphenyl-4-yl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 862650-83-7
2'-methyl-4'-hydroxy-5'-(adamantan-1-yl)biphenyl-4-aldehyde

: 21204-67-1,2605-67-6
methyl (triphenylphosphoranylidene)acetate

: 862650-94-0
methyl E-3-[3'-(adamantan-1-yl)-2'-methyl-4'-hydroxybiphenyl-4-yl]acrylate

Guidance literature:: In chloroform; for 5h; Heating;
DOI:10.1021/jm049440h

Reference yield:

: 245434-50-8
2-(adamantan-1-yl)-5-methyl-4-bromophenol

: 862650-94-0
methyl E-3-[3'-(adamantan-1-yl)-2'-methyl-4'-hydroxybiphenyl-4-yl]acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / aq. Na₂CO₃; Pd(PPh₃)4 / toluene; ethanol / 3 h / Heating

2: 80 percent / CHCl₃ / 5 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; chloroform; toluene; 1: Suzuki coupling / 2: Wittig reaction;
DOI:10.1021/jm049440h

Reference yield:

: 14472-14-1
4-bromo-3-methylphenol

: 862650-94-0
methyl E-3-[3'-(adamantan-1-yl)-2'-methyl-4'-hydroxybiphenyl-4-yl]acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / AcOH; H₂SO₄ / 96 h / 20 °C

2: 55 percent / aq. Na₂CO₃; Pd(PPh₃)4 / toluene; ethanol / 3 h / Heating

3: 80 percent / CHCl₃ / 5 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; sodium carbonate; acetic acid; In ethanol; chloroform; toluene; 2: Suzuki coupling / 3: Wittig reaction;
DOI:10.1021/jm049440h