(2R,3R,4S,5R)-4-Fluoro-2-hydroxymethyl-5-imidazo[2,1-i]purin-3-yl-tetrahydro-furan-3-ol

Base Information

Chemical Name:(2R,3R,4S,5R)-4-Fluoro-2-hydroxymethyl-5-imidazo[2,1-i]purin-3-yl-tetrahydro-furan-3-ol
CAS No.:170658-49-8
Molecular Formula:C₁₂H₁₂FN₅O₃
Molecular Weight:293.257
Hs Code.:

Synonyms:(2R,3R,4S,5R)-4-Fluoro-2-hydroxymethyl-5-imidazo[2,1-i]purin-3-yl-tetrahydro-furan-3-ol

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Chemical Property of (2R,3R,4S,5R)-4-Fluoro-2-hydroxymethyl-5-imidazo[2,1-i]purin-3-yl-tetrahydro-furan-3-ol

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Technology Process of (2R,3R,4S,5R)-4-Fluoro-2-hydroxymethyl-5-imidazo[2,1-i]purin-3-yl-tetrahydro-furan-3-ol

There total 1 articles about (2R,3R,4S,5R)-4-Fluoro-2-hydroxymethyl-5-imidazo[2,1-i]purin-3-yl-tetrahydro-furan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22224-41-5
1,3,5-tri-O-benzoyl-α-D-ribofuranoside

: 170658-49-8
(2R,3R,4S,5R)-4-Fluoro-2-hydroxymethyl-5-imidazo[2,1-i]purin-3-yl-tetrahydro-furan-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / (diethylamino)sulfur trifluoride / CH₂Cl₂ / 40 °C

2: 96 percent / HBr, AcOH / CH₂Cl₂

3: 51 percent / NaH / acetonitrile / 50 °C

4: 70 percent / NH₃ / methanol / Heating

5: 90 percent / aq. buffer (pH=4.5)

With diethylamino-sulfur trifluoride; ammonia; hydrogen bromide; sodium hydride; acetic acid; In methanol; dichloromethane; acetonitrile;

Reference yield: 71.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 170658-49-8
(2R,3R,4S,5R)-4-Fluoro-2-hydroxymethyl-5-imidazo[2,1-i]purin-3-yl-tetrahydro-furan-3-ol

: (2R,3R,4S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-fluoro-5-imidazo[2,1-i]purin-3-yl-tetrahydro-furan-3-ol

Guidance literature:: With pyridine; dmap; triethylamine;

Reference yield:

: 170658-49-8
(2R,3R,4S,5R)-4-Fluoro-2-hydroxymethyl-5-imidazo[2,1-i]purin-3-yl-tetrahydro-furan-3-ol

: Diisopropyl-phosphoramidous acid (2R,3R,4S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-fluoro-5-imidazo[2,1-i]purin-3-yl-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / DMAP, Et₃N, pyridine

2: 86 percent / i-Pr₂NEt / tetrahydrofuran

With pyridine; dmap; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;