N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(2-{[(methoxy)acetyl]amino}phenyl)-1-benzofuran-2-carboxamide chloride

Base Information

Chemical Name:N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(2-{[(methoxy)acetyl]amino}phenyl)-1-benzofuran-2-carboxamide chloride
CAS No.:634904-29-3
Molecular Formula:C₂₅H₂₇N₃O₄*ClH
Molecular Weight:469.968
Hs Code.:

Synonyms:N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(2-{[(methoxy)acetyl]amino}phenyl)-1-benzofuran-2-carboxamide chloride

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Chemical Property of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(2-{[(methoxy)acetyl]amino}phenyl)-1-benzofuran-2-carboxamide chloride

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Technology Process of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(2-{[(methoxy)acetyl]amino}phenyl)-1-benzofuran-2-carboxamide chloride

There total 7 articles about N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(2-{[(methoxy)acetyl]amino}phenyl)-1-benzofuran-2-carboxamide chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(2-{[(methoxy)acetyl]amino}phenyl)-1-benzofuran-2-carboxamide

: 634904-29-3
N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(2-{[(methoxy)acetyl]amino}phenyl)-1-benzofuran-2-carboxamide chloride

Guidance literature:: With hydrogenchloride; In methanol; water;

Reference yield:

: N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-bromo-1-benzofuran-2-carboxamide

: 634904-29-3
N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(2-{[(methoxy)acetyl]amino}phenyl)-1-benzofuran-2-carboxamide chloride

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / methanol; water

2: sodium hydroxide / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / DMF (N,N-dimethyl-formamide); water / 95 °C

3: triethylamine / tetrahydrofuran; DMF (N,N-dimethyl-formamide) / 20 °C

4: hydrogenchloride / methanol; water

With hydrogenchloride; sodium hydroxide; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); water;

Reference yield:

: N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-bromo-1-benzofuran-2-carboxamide hydrochloride

: 634904-29-3
N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(2-{[(methoxy)acetyl]amino}phenyl)-1-benzofuran-2-carboxamide chloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / DMF (N,N-dimethyl-formamide); water / 95 °C

2: triethylamine / tetrahydrofuran; DMF (N,N-dimethyl-formamide) / 20 °C

3: hydrogenchloride / methanol; water

With hydrogenchloride; sodium hydroxide; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); water;