Carbonic acid (2R,6R)-6-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-2-methyl-heptyl ester methyl ester

Base Information

Chemical Name:Carbonic acid (2R,6R)-6-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-2-methyl-heptyl ester methyl ester
CAS No.:202462-21-3
Molecular Formula:C₅₆H₇₇N₃O₉
Molecular Weight:936.242
Hs Code.:

Carbonic acid (2R,6R)-6-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-2-methyl-heptyl ester methyl ester

Synonyms:Carbonic acid (2R,6R)-6-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-2-methyl-heptyl ester methyl ester

Suppliers and Price of Carbonic acid (2R,6R)-6-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-2-methyl-heptyl ester methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Carbonic acid (2R,6R)-6-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-2-methyl-heptyl ester methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Carbonic acid (2R,6R)-6-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-2-methyl-heptyl ester methyl ester

There total 10 articles about Carbonic acid (2R,6R)-6-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-2-methyl-heptyl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 202462-19-9
C₇₂H₉₅N₃O₉Si

: 202462-21-3
Carbonic acid (2R,6R)-6-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-2-methyl-heptyl ester methyl ester

Guidance literature:: With hydrogen fluoride; In acetonitrile; for 3.5h; Ambient temperature;
DOI:10.1016/S0968-0896(97)00170-3

Reference yield:

: 33628-52-3
3α,7α-diacetoxy-24-phenyl-5β-cholan-24-oic acid

: 202462-21-3
Carbonic acid (2R,6R)-6-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-2-methyl-heptyl ester methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) Pb(OAc)4, 2.) I₂ / 1.) CCl₄, irradiation, reflux, 20 min, 2.) CCl₄, reflux, 70 min

2: 90 percent / DMSO, 2,4,6-collidine / 1.5 h / 150 °C

3: 1.) NaN(SiMe₃)2 / 1.) THF, RT, 30 min, 2.) THF, 0 deg C, 1 h

4: 92 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

5: dimethylformamide / 17 h / Ambient temperature

6: H₂ / Pd(OH)2/C / ethanol / 96 h

7: 95 percent / pyridine / CH₂Cl₂ / 4 h / 0 °C

8: 1.) 2,6-di-tert-butyl-4-methylpyridine, triflic anhydride / 1.) CH₂Cl₂, -78 deg C, 5 min, 2.) CH₂Cl₂, from -78 deg C to -20 deg C

9: 96 percent / 46percent aq. HF / acetonitrile / 3.5 h / Ambient temperature

With pyridine; 2,4,6-trimethyl-pyridine; lead(IV) acetate; lithium aluminium tetrahydride; 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride; hydrogen fluoride; hydrogen; iodine; sodium hexamethyldisilazane; dimethyl sulfoxide; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0968-0896(97)00170-3

Reference yield:

: 474-25-9
chenodeoxycholic acid

: 202462-21-3
Carbonic acid (2R,6R)-6-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-((2R,3R,4R,5S,6R)-3-azido-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-2-methyl-heptyl ester methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 88 percent / 4-dimethylaminopyridine, pyridine / 4 h / Ambient temperature

2: 1.) Pb(OAc)4, 2.) I₂ / 1.) CCl₄, irradiation, reflux, 20 min, 2.) CCl₄, reflux, 70 min

3: 90 percent / DMSO, 2,4,6-collidine / 1.5 h / 150 °C

4: 1.) NaN(SiMe₃)2 / 1.) THF, RT, 30 min, 2.) THF, 0 deg C, 1 h

5: 92 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

6: dimethylformamide / 17 h / Ambient temperature

7: H₂ / Pd(OH)2/C / ethanol / 96 h

8: 95 percent / pyridine / CH₂Cl₂ / 4 h / 0 °C

9: 1.) 2,6-di-tert-butyl-4-methylpyridine, triflic anhydride / 1.) CH₂Cl₂, -78 deg C, 5 min, 2.) CH₂Cl₂, from -78 deg C to -20 deg C

10: 96 percent / 46percent aq. HF / acetonitrile / 3.5 h / Ambient temperature

With pyridine; 2,4,6-trimethyl-pyridine; lead(IV) acetate; dmap; lithium aluminium tetrahydride; 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride; hydrogen fluoride; hydrogen; iodine; sodium hexamethyldisilazane; dimethyl sulfoxide; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0968-0896(97)00170-3