tert-butyl 4-(4-((4-(3-carbamoylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-((4-(3-carbamoylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate
CAS No.:1393901-82-0
Molecular Formula:C₃₀H₃₅F₃N₆O₃
Molecular Weight:584.642
Hs Code.:

Synonyms:tert-butyl 4-(4-((4-(3-carbamoylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-((4-(3-carbamoylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(4-((4-(3-carbamoylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

There total 10 articles about tert-butyl 4-(4-((4-(3-carbamoylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1393901-81-9
tert-butyl 4-(4-((4-((3-carbamoylphenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

: 1393901-82-0
tert-butyl 4-(4-((4-(3-carbamoylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

Guidance literature:: With hydrogen; triethylamine; palladium on activated charcoal; In N,N-dimethyl-formamide; at 30 ℃; for 18h;

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 1393901-82-0
tert-butyl 4-(4-((4-(3-carbamoylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 2585.81 Torr

3.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 1 h / 0 °C

3.2: 20 °C / Cooling with ice

4.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.25 h / 120 °C / microwave irradiation; Inert atmosphere

5.1: triethylamine; hydrogen / palladium on activated charcoal / N,N-dimethyl-formamide / 18 h / 30 °C

With hydrogen; sodium carbonate; triethylamine; zinc(II) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; palladium on activated charcoal; triphenylphosphine; In diethyl ether; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 130636-61-2
1-[(4-nitrophenyl)methyl]-4-tert-butyloxycarbonylpiperazine

: 1393901-82-0
tert-butyl 4-(4-((4-(3-carbamoylphenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 2585.81 Torr

2.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 1 h / 0 °C

2.2: 20 °C / Cooling with ice

3.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.25 h / 120 °C / microwave irradiation; Inert atmosphere

4.1: triethylamine; hydrogen / palladium on activated charcoal / N,N-dimethyl-formamide / 18 h / 30 °C

With hydrogen; triethylamine; zinc(II) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; palladium on activated charcoal; triphenylphosphine; In diethyl ether; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;