(2R)-N-[(3,5-dichlorophenyl)methyl]-2-(4-methyl-1-piperazinyl)-2-(1-naphthalenyl)ethanamide hydrochloride

Base Information

Chemical Name:(2R)-N-[(3,5-dichlorophenyl)methyl]-2-(4-methyl-1-piperazinyl)-2-(1-naphthalenyl)ethanamide hydrochloride
CAS No.:1090513-01-1
Molecular Formula:C₂₄H₂₅Cl₂N₃O*ClH
Molecular Weight:478.849
Hs Code.:

Synonyms:(2R)-N-[(3,5-dichlorophenyl)methyl]-2-(4-methyl-1-piperazinyl)-2-(1-naphthalenyl)ethanamide hydrochloride

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Chemical Property of (2R)-N-[(3,5-dichlorophenyl)methyl]-2-(4-methyl-1-piperazinyl)-2-(1-naphthalenyl)ethanamide hydrochloride

Chemical Property:

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Technology Process of (2R)-N-[(3,5-dichlorophenyl)methyl]-2-(4-methyl-1-piperazinyl)-2-(1-naphthalenyl)ethanamide hydrochloride

There total 5 articles about (2R)-N-[(3,5-dichlorophenyl)methyl]-2-(4-methyl-1-piperazinyl)-2-(1-naphthalenyl)ethanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1090513-00-0
(2R)-N-[(3,5-dichlorophenyl)methyl]-2-(4-methyl-1-piperazinyl)-2-(1-naphthalenyl)ethanamide

: 1090513-01-1
(2R)-N-[(3,5-dichlorophenyl)methyl]-2-(4-methyl-1-piperazinyl)-2-(1-naphthalenyl)ethanamide hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; for 0.5h;

Reference yield:

: 13922-41-3
1-Naphthylboronic acid

: 1090513-01-1
(2R)-N-[(3,5-dichlorophenyl)methyl]-2-(4-methyl-1-piperazinyl)-2-(1-naphthalenyl)ethanamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetonitrile / 24 h / Heating / reflux

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h

2.2: 48 h / 20 °C

3.1: acetone / 3 h / Resolution of racemate

4.1: water; potassium carbonate / dichloromethane

5.1: hydrogenchloride / diethyl ether; dichloromethane / 0.5 h

With hydrogenchloride; water; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 1090513-02-2
(+/-)-(4-methyl-1-piperazinyl)(1-naphthalenyl)acetic acid

: 1090513-01-1
(2R)-N-[(3,5-dichlorophenyl)methyl]-2-(4-methyl-1-piperazinyl)-2-(1-naphthalenyl)ethanamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h

1.2: 48 h / 20 °C

2.1: acetone / 3 h / Resolution of racemate

3.1: water; potassium carbonate / dichloromethane

4.1: hydrogenchloride / diethyl ether; dichloromethane / 0.5 h

With hydrogenchloride; water; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone;