methyl 3-((3-carbamoyl-6-(cyclobutylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoate

Base Information

Chemical Name:methyl 3-((3-carbamoyl-6-(cyclobutylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoate
CAS No.:1445790-24-8
Molecular Formula:C₃₄H₃₇N₅O₆
Molecular Weight:611.698
Hs Code.:

Synonyms:methyl 3-((3-carbamoyl-6-(cyclobutylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoate

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Chemical Property of methyl 3-((3-carbamoyl-6-(cyclobutylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoate

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Technology Process of methyl 3-((3-carbamoyl-6-(cyclobutylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoate

There total 13 articles about methyl 3-((3-carbamoyl-6-(cyclobutylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1445790-22-6
methyl 3-(3-carbamoyl-7-chloro-6-(cyclobutylmethoxy)quinolin-4-ylamino)-5-cyclopentylbenzoate

: 89641-18-9
2,4-dimethoxypyrimidin-5-ylboronic acid

: 1445790-24-8
methyl 3-((3-carbamoyl-6-(cyclobutylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 80 ℃; for 24h; Inert atmosphere;

Reference yield:

: 351892-49-4
diethyl 2-((3-chloro-4-methoxyphenylamino)methylene)malonate

: 1445790-24-8
methyl 3-((3-carbamoyl-6-(cyclobutylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: diethyl ether / 1.5 h / 220 °C

2.1: sodium hydroxide; water / ethanol / 3 h / 100 °C

3.1: trichlorophosphate; water / 3 h / Reflux

4.1: ammonium hydroxide / tetrahydrofuran / 0 °C

5.1: boron tribromide / 1,2-dichloro-ethane / 0 - 75 °C / Inert atmosphere

5.2: 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C

7.1: ethanol / Reflux

8.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 24 h / 80 °C / Inert atmosphere

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; boron tribromide; potassium carbonate; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: C₁₁H₇Cl₂NO₃

: 1445790-24-8
methyl 3-((3-carbamoyl-6-(cyclobutylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium hydroxide / tetrahydrofuran / 0 °C

2.1: boron tribromide / 1,2-dichloro-ethane / 0 - 75 °C / Inert atmosphere

2.2: 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C

4.1: ethanol / Reflux

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 24 h / 80 °C / Inert atmosphere

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;