1,2,3,4-tetrahydro-1-(3-methoxycarbonylpropyl)-2-benzyl-β-carboline

Base Information

• Chemical Name: 1,2,3,4-tetrahydro-1-(3-methoxycarbonylpropyl)-2-benzyl-β-carboline
• CAS No.: 75622-27-4
• Molecular Formula: C₂₃H₂₆N₂O₂
• Molecular Weight: 362.472
• Mol file: 75622-27-4.mol

Synonyms:1,2,3,4-tetrahydro-1-(3-methoxycarbonylpropyl)-2-benzyl-β-carboline

Chemical Property of 1,2,3,4-tetrahydro-1-(3-methoxycarbonylpropyl)-2-benzyl-β-carboline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2,3,4-tetrahydro-1-(3-methoxycarbonylpropyl)-2-benzyl-β-carboline

There total 4 articles about 1,2,3,4-tetrahydro-1-(3-methoxycarbonylpropyl)-2-benzyl-β-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-[2-(2-Benzyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-ethyl]-malonic acid dimethyl ester (115757-56-7) → 1,2,3,4-tetrahydro-1-(3-methoxycarbonylpropyl)-2-benzyl-β-carboline (75622-27-4)

Guidance literature:

With lithium chloride; In water; dimethyl sulfoxide; for 2h; Heating;

DOI:10.1021/jo00253a014

Reference yield: 68.0%

→ 1,2,3,4-tetrahydro-1-(3-methoxycarbonylpropyl)-2-benzyl-β-carboline (75622-27-4)

Guidance literature:

Reference yield:

N-benzyl tryptamine (15741-79-4) → 1,2,3,4-tetrahydro-1-(3-methoxycarbonylpropyl)-2-benzyl-β-carboline (75622-27-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) CH₃COOH / 1.) toluene, reflux, 30 min, 2.) reflux, 2 h

2: 73 percent / LiCl / dimethylsulfoxide; H₂O / 2 h / Heating

With acetic acid; lithium chloride; In water; dimethyl sulfoxide;

DOI:10.1021/jo00253a014

upstream raw materials:

2-[2-(2-Benzyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-ethyl]-malonic acid dimethyl ester

N-benzyl tryptamine

formyl-4 methoxycarbonyl-2 butanoate de methyle

Downstream raw materials:

1,2,3,3a,4,5,6,7-octahydro-3-benzyl-7-oxo-azepino[1,2,3-lm]-β-carboline

1,2,3,4,6,7,12,12b-octahydroindolo(2,3-a)quinolizine