2-[4-(2-carboxyethyl)-5-{5-[3-(2-carboxyethyl)-5-(2-carboxyphenyl)thiophen-2-yl]thiophen-2-yl}thiophen-2-yl]benzoic acid

Base Information

Chemical Name:2-[4-(2-carboxyethyl)-5-{5-[3-(2-carboxyethyl)-5-(2-carboxyphenyl)thiophen-2-yl]thiophen-2-yl}thiophen-2-yl]benzoic acid
CAS No.:1419170-27-6
Molecular Formula:C₃₂H₂₄O₈S₃
Molecular Weight:632.736
Hs Code.:

Synonyms:2-[4-(2-carboxyethyl)-5-{5-[3-(2-carboxyethyl)-5-(2-carboxyphenyl)thiophen-2-yl]thiophen-2-yl}thiophen-2-yl]benzoic acid

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Chemical Property of 2-[4-(2-carboxyethyl)-5-{5-[3-(2-carboxyethyl)-5-(2-carboxyphenyl)thiophen-2-yl]thiophen-2-yl}thiophen-2-yl]benzoic acid

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Technology Process of 2-[4-(2-carboxyethyl)-5-{5-[3-(2-carboxyethyl)-5-(2-carboxyphenyl)thiophen-2-yl]thiophen-2-yl}thiophen-2-yl]benzoic acid

There total 7 articles about 2-[4-(2-carboxyethyl)-5-{5-[3-(2-carboxyethyl)-5-(2-carboxyphenyl)thiophen-2-yl]thiophen-2-yl}thiophen-2-yl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1419172-26-1
C₃₆H₃₂O₈S₃

: 1419170-27-6
2-[4-(2-carboxyethyl)-5-{5-[3-(2-carboxyethyl)-5-(2-carboxyphenyl)thiophen-2-yl]thiophen-2-yl}thiophen-2-yl]benzoic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 60 ℃; for 0.5h;

Reference yield:

: 1419171-80-4
methyl 3-(2-{5-[3-(3-methoxy-3-oxopropyl)thiophen-2-yl]thiophen-2-yl}thiophen-3-yl)propanoate

: 1419170-27-6
2-[4-(2-carboxyethyl)-5-{5-[3-(2-carboxyethyl)-5-(2-carboxyphenyl)thiophen-2-yl]thiophen-2-yl}thiophen-2-yl]benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; acetic acid / chloroform / 5 - 20 °C

2: potassium carbonate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride / toluene; methanol / 2 h / 60 °C / Inert atmosphere

3: sodium hydroxide / 1,4-dioxane / 0.5 h / 60 °C

With N-Bromosuccinimide; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium carbonate; acetic acid; sodium hydroxide; In 1,4-dioxane; methanol; chloroform; toluene; 2: |Suzuki Coupling;

Reference yield:

: 1195-52-4,102696-71-9
trans-3-(3-thienyl)acrylic acid

: 1419170-27-6
2-[4-(2-carboxyethyl)-5-{5-[3-(2-carboxyethyl)-5-(2-carboxyphenyl)thiophen-2-yl]thiophen-2-yl}thiophen-2-yl]benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: palladium 10% on activated carbon; hydrogen / methanol; acetic acid / 12 h / 50 °C

2: thionyl chloride / 3 h / 0 - 20 °C

3: N-Bromosuccinimide; acetic acid / chloroform / 5 - 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 12 h / 20 °C

5: N-Bromosuccinimide; acetic acid / chloroform / 5 - 20 °C

6: potassium carbonate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride / toluene; methanol / 2 h / 60 °C / Inert atmosphere

7: sodium hydroxide / 1,4-dioxane / 0.5 h / 60 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; sodium hydroxide; In 1,4-dioxane; methanol; chloroform; acetic acid; toluene; 4: |Stille Cross Coupling / 6: |Suzuki Coupling;