3-chloro-5((4-(1,1-difluoromethyl)-1-((6-(difluoromethyl)-3-oxo-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Base Information

Chemical Name:3-chloro-5((4-(1,1-difluoromethyl)-1-((6-(difluoromethyl)-3-oxo-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile
CAS No.:1591826-79-7
Molecular Formula:C₁₈H₁₀ClF₄N₅O₃
Molecular Weight:455.756
Hs Code.:

Synonyms:3-chloro-5((4-(1,1-difluoromethyl)-1-((6-(difluoromethyl)-3-oxo-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

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Chemical Property of 3-chloro-5((4-(1,1-difluoromethyl)-1-((6-(difluoromethyl)-3-oxo-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

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Technology Process of 3-chloro-5((4-(1,1-difluoromethyl)-1-((6-(difluoromethyl)-3-oxo-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

There total 13 articles about 3-chloro-5((4-(1,1-difluoromethyl)-1-((6-(difluoromethyl)-3-oxo-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-chloro-5-((4-(difluoromethyl)-1-((6-(difluoromethyl)-3-methoxypyridazin-4-yl)methyl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

: 1591826-79-7
3-chloro-5((4-(1,1-difluoromethyl)-1-((6-(difluoromethyl)-3-oxo-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: With chloro-trimethyl-silane; potassium iodide; In acetonitrile; at 70 ℃; for 1.5h;

Reference yield:

: 6-(difluoromethyl)pyrimidin-4(3H)-one

: 1591826-79-7
3-chloro-5((4-(1,1-difluoromethyl)-1-((6-(difluoromethyl)-3-oxo-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid; potassium acetate; bromine / 4 h / 80 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

3: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 120 °C

4: trifluoroacetic acid / 0.17 h / 100 °C / Microwave irradiation

5: potassium carbonate; lithium bromide / N,N-dimethyl-formamide / 20 °C

6: potassium iodide; chloro-trimethyl-silane / acetonitrile / 1.5 h / 70 °C

With chloro-trimethyl-silane; potassium tert-butylate; bromine; potassium acetate; potassium carbonate; acetic acid; trifluoroacetic acid; potassium iodide; lithium bromide; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 677777-60-5
5-bromo-6-(difluoromethyl)pyrimidin-4(3H)-one

: 1591826-79-7
3-chloro-5((4-(1,1-difluoromethyl)-1-((6-(difluoromethyl)-3-oxo-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

2: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 120 °C

3: trifluoroacetic acid / 0.17 h / 100 °C / Microwave irradiation

4: potassium carbonate; lithium bromide / N,N-dimethyl-formamide / 20 °C

5: potassium iodide; chloro-trimethyl-silane / acetonitrile / 1.5 h / 70 °C

With chloro-trimethyl-silane; potassium tert-butylate; potassium carbonate; trifluoroacetic acid; potassium iodide; lithium bromide; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; acetonitrile;