benzyl (2S,3S)-3-methyl-2-phthalimido-pentanoate

Base Information

Chemical Name:benzyl (2S,3S)-3-methyl-2-phthalimido-pentanoate
CAS No.:42406-41-7
Molecular Formula:C₂₁H₂₁NO₄
Molecular Weight:351.402
Hs Code.:

Synonyms:benzyl (2S,3S)-3-methyl-2-phthalimido-pentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (2S,3S)-3-methyl-2-phthalimido-pentanoate

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

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Technology Process of benzyl (2S,3S)-3-methyl-2-phthalimido-pentanoate

There total 3 articles about benzyl (2S,3S)-3-methyl-2-phthalimido-pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 157919-58-9
benzyl (2S,3S)-N-<2-(methoxycarbonyl)-benzoyl>-2-amino-3-methyl-pentanoate

: 42406-41-7
benzyl (2S,3S)-3-methyl-2-phthalimido-pentanoate

Guidance literature:: With sodium hydroxide; tetrabutylammomium bromide; In dichloromethane; water; for 1.16667h;
DOI:10.1016/S0040-4020(01)85232-7

Reference yield:

: 4376-18-5
Monomethyl phthalate

: 42406-41-7
benzyl (2S,3S)-3-methyl-2-phthalimido-pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) thionyl chloride, DMF, 3.) triethylamine / 1.) reflux, 1 h, 2.) benzene, 3.) THF, 0 deg C, 2 h

2: 88 percent / Bu₄NBr, 5percent NaOH / CH₂Cl₂; H₂O / 1.17 h

With sodium hydroxide; thionyl chloride; tetrabutylammomium bromide; triethylamine; N,N-dimethyl-formamide; In dichloromethane; water;
DOI:10.1016/S0040-4020(01)85232-7

Reference yield:

: 4376-18-5
Monomethyl phthalate

: 16652-75-8
L-isoleucine benzyl ester tosylate

: 42406-41-7
benzyl (2S,3S)-3-methyl-2-phthalimido-pentanoate

: 157919-58-9
benzyl (2S,3S)-N-<2-(methoxycarbonyl)-benzoyl>-2-amino-3-methyl-pentanoate

Guidance literature:: With thionyl chloride; triethylamine; N,N-dimethyl-formamide; Yield given; 1.) reflux, 1 h, 2.) benzene, 3.) THF, 0 deg C, 2 h;
DOI:10.1016/S0040-4020(01)85232-7