[3-(6-amino-purin-7-yl)-4-trityloxy-butoxymethyl]phosphonic acid diisopropyl ester

Base Information

Chemical Name:[3-(6-amino-purin-7-yl)-4-trityloxy-butoxymethyl]phosphonic acid diisopropyl ester
CAS No.:918795-52-5
Molecular Formula:C₃₅H₄₂N₅O₅P
Molecular Weight:643.723
Hs Code.:

Synonyms:[3-(6-amino-purin-7-yl)-4-trityloxy-butoxymethyl]phosphonic acid diisopropyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [3-(6-amino-purin-7-yl)-4-trityloxy-butoxymethyl]phosphonic acid diisopropyl ester

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Technology Process of [3-(6-amino-purin-7-yl)-4-trityloxy-butoxymethyl]phosphonic acid diisopropyl ester

There total 12 articles about [3-(6-amino-purin-7-yl)-4-trityloxy-butoxymethyl]phosphonic acid diisopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: {3-[6-(dimethylamino-methyleneamino)-purin-7-yl]-4-trityloxy-butoxy-methyl}-phosphonic acid diisopropyl ester

: 918795-52-5
[3-(6-amino-purin-7-yl)-4-trityloxy-butoxymethyl]phosphonic acid diisopropyl ester

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 96h;
DOI:10.1080/15257770500446816

Reference yield: 8.0%

: 918795-50-3
3-(6-amino-purin-7-yl)-4-trityloxy-butan-1-ol

: 35717-98-7
bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate

: 918795-52-5
[3-(6-amino-purin-7-yl)-4-trityloxy-butoxymethyl]phosphonic acid diisopropyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 20 - 50 ℃; for 3.5h;
DOI:10.1080/15257770500446816

Reference yield:

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 918795-52-5
[3-(6-amino-purin-7-yl)-4-trityloxy-butoxymethyl]phosphonic acid diisopropyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 70 percent / dimethylformamide / 1 h / Heating

2.1: 38 percent / NaH / dimethylformamide / 16 h / 20 °C

3.1: 52 percent / sodium borohydride / methanol / 11 h / -5 - 0 °C

4.1: pyridine; DMAP / 48 h / 20 °C

5.1: 0.3 g / aq. NaOH / methanol / 48 h / 20 °C

6.1: ozone / methanol; H₂O / -78 °C

6.2: 53 percent / sodium borohydride / methanol; H₂O / -78 - 20 °C

7.1: 8 percent / dimethylformamide / 3.5 h / 20 - 50 °C

With pyridine; dmap; sodium hydroxide; sodium tetrahydroborate; sodium hydride; ozone; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1080/15257770500446816