4-(4-benzylpiperazin-1-yl)-6-oxo-3,6-dihydro-2H-naphtho[1,2-b]pyrano[2,3-d]oxepine-5-carbonitrile

Base Information

• Chemical Name: 4-(4-benzylpiperazin-1-yl)-6-oxo-3,6-dihydro-2H-naphtho[1,2-b]pyrano[2,3-d]oxepine-5-carbonitrile
• CAS No.: 1384168-56-2
• Molecular Formula: C₂₉H₂₅N₃O₃
• Molecular Weight: 463.536

Synonyms:4-(4-benzylpiperazin-1-yl)-6-oxo-3,6-dihydro-2H-naphtho[1,2-b]pyrano[2,3-d]oxepine-5-carbonitrile

Chemical Property of 4-(4-benzylpiperazin-1-yl)-6-oxo-3,6-dihydro-2H-naphtho[1,2-b]pyrano[2,3-d]oxepine-5-carbonitrile

Chemical Property:

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Technology Process of 4-(4-benzylpiperazin-1-yl)-6-oxo-3,6-dihydro-2H-naphtho[1,2-b]pyrano[2,3-d]oxepine-5-carbonitrile

There total 2 articles about 4-(4-benzylpiperazin-1-yl)-6-oxo-3,6-dihydro-2H-naphtho[1,2-b]pyrano[2,3-d]oxepine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

1-phenylmethylpiperazine (2759-28-6) + 4-(methylthio)-6-oxo-3,6-dihydro-2H-naphtho[1,2-b]pyrano[2,3-d]oxepine-5-carbonitrile (1384168-55-1) → 4-(4-benzylpiperazin-1-yl)-6-oxo-3,6-dihydro-2H-naphtho[1,2-b]pyrano[2,3-d]oxepine-5-carbonitrile (1384168-56-2)

Guidance literature:

In methanol; for 5h; Reflux;

DOI:10.1039/c2ob25173f

Reference yield:

9,10-dihydro-8H-11-oxa-cyclohepta[a]naphthalen-7-one (16563-58-9) → 4-(4-benzylpiperazin-1-yl)-6-oxo-3,6-dihydro-2H-naphtho[1,2-b]pyrano[2,3-d]oxepine-5-carbonitrile (1384168-56-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / N,N-dimethyl-formamide / 3 h / 20 °C

2: methanol / 5 h / Reflux

With potassium hydroxide; In methanol; N,N-dimethyl-formamide;

DOI:10.1039/c2ob25173f

Reference yield: 50.0%

4-(4-benzylpiperazin-1-yl)-6-oxo-3,6-dihydro-2H-naphtho[1,2-b]pyrano[2,3-d]oxepine-5-carbonitrile (1384168-56-2) + benzamidin (618-39-3) → C25H17N3O3 (1384168-57-3)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

DOI:10.1039/c2ob25173f

upstream raw materials:

1-phenylmethylpiperazine

4-(methylthio)-6-oxo-3,6-dihydro-2H-naphtho[1,2-b]pyrano[2,3-d]oxepine-5-carbonitrile

9,10-dihydro-8H-11-oxa-cyclohepta[a]naphthalen-7-one

Downstream raw materials:

C₂₅H₁₇N₃O₃

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