Technology Process of 7-phenyl-2-(S)-(pyrrolidin-2-yl)thiazolo[5,4-b]pyridine hydrochloride
There total 9 articles about 7-phenyl-2-(S)-(pyrrolidin-2-yl)thiazolo[5,4-b]pyridine hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C24H21N3O2S;
With
methyl-phenyl-thioether; trifluoroacetic acid;
at 40 ℃;
for 16h;
With
sodium hydroxide;
In
diethyl ether; water;
With
hydrogenchloride;
In
1,4-dioxane; diethyl ether;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / water; N,N-dimethyl-formamide / 0.67 h / 130 °C / Microwave
2: pyridine / dichloromethane / 16 h
3: Lawessons reagent / toluene / 100 °C
4: methyl-phenyl-thioether; trifluoroacetic acid / 16 h / 40 °C
With
Lawessons reagent; pyridine; methyl-phenyl-thioether; potassium carbonate; trifluoroacetic acid;
tetrakis(triphenylphosphine) palladium(0);
In
dichloromethane; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / water; N,N-dimethyl-formamide / 0.67 h / 130 °C / Microwave
2: pyridine / dichloromethane / 16 h
3: Lawessons reagent / toluene / 100 °C
4: methyl-phenyl-thioether; trifluoroacetic acid / 16 h / 40 °C
With
Lawessons reagent; pyridine; methyl-phenyl-thioether; potassium carbonate; trifluoroacetic acid;
tetrakis(triphenylphosphine) palladium(0);
In
dichloromethane; water; N,N-dimethyl-formamide; toluene;
