1,4-dimethyl-6-<<(1-phenylmethoxycarbonyl)indol-3-yl>methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione

Base Information

• Chemical Name: 1,4-dimethyl-6-<<(1-phenylmethoxycarbonyl)indol-3-yl>methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione
• CAS No.: 180857-78-7
• Molecular Formula: C₃₇H₃₃N₃O₅
• Molecular Weight: 599.686
• Mol file: 180857-78-7.mol

Synonyms:1,4-dimethyl-6-<<(1-phenylmethoxycarbonyl)indol-3-yl>methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione

Chemical Property of 1,4-dimethyl-6-<<(1-phenylmethoxycarbonyl)indol-3-yl>methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-dimethyl-6-<<(1-phenylmethoxycarbonyl)indol-3-yl>methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione

There total 3 articles about 1,4-dimethyl-6-<<(1-phenylmethoxycarbonyl)indol-3-yl>methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

benzyl chloroformate (501-53-1,94274-21-2) + 1,4-dimethyl-6-<(1H-indol-3-yl)methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione (180857-76-5) → 1,4-dimethyl-6-<<(1-phenylmethoxycarbonyl)indol-3-yl>methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione (180857-78-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 2h; Ambient temperature;

DOI:10.1016/0040-4020(96)00408-5

Reference yield:

1,4-dimethyl-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione (149862-46-4) → 1,4-dimethyl-6-<<(1-phenylmethoxycarbonyl)indol-3-yl>methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione (180857-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LDA, Li₂CuCl₄ / 1.) THF, hexane, -78 deg C, 2.) THF, hexane, -78 deg C, 40 min

2: 70 percent / NaH / dimethylformamide / 2 h / Ambient temperature

With dilithium tetrachlorocuprate; sodium hydride; lithium diisopropyl amide; In N,N-dimethyl-formamide;

DOI:10.1016/0040-4020(96)00408-5

Reference yield:

Methanesulfonate(1H-indol-3-ylmethyl)-trimethyl-ammonium; → 1,4-dimethyl-6-<<(1-phenylmethoxycarbonyl)indol-3-yl>methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione (180857-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LDA, Li₂CuCl₄ / 1.) THF, hexane, -78 deg C, 2.) THF, hexane, -78 deg C, 40 min

2: 70 percent / NaH / dimethylformamide / 2 h / Ambient temperature

With dilithium tetrachlorocuprate; sodium hydride; lithium diisopropyl amide; In N,N-dimethyl-formamide;

DOI:10.1016/0040-4020(96)00408-5

upstream raw materials:

benzyl chloroformate

1,4-dimethyl-6-<(1H-indol-3-yl)methyl>-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione

1,4-dimethyl-3-<(3-phenylmethoxy)phenylmethylene>-(Z)-2,5-piperazinedione