N-[(1S)-1-(4-fluorophenyl)ethyl]-4-methyl-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-3-pyridazinamine

Base Information

• Chemical Name: N-[(1S)-1-(4-fluorophenyl)ethyl]-4-methyl-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-3-pyridazinamine
• CAS No.: 1145785-97-2
• Molecular Formula: C₂₄H₂₄FN₅O
• Molecular Weight: 417.486
• Mol file: 1145785-97-2.mol

Synonyms:N-[(1S)-1-(4-fluorophenyl)ethyl]-4-methyl-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-3-pyridazinamine

Chemical Property of N-[(1S)-1-(4-fluorophenyl)ethyl]-4-methyl-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-3-pyridazinamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(1S)-1-(4-fluorophenyl)ethyl]-4-methyl-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-3-pyridazinamine

There total 2 articles about N-[(1S)-1-(4-fluorophenyl)ethyl]-4-methyl-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-3-pyridazinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]boronic acid (1145786-45-3) + 6-chloro-N-[(1S)-1-(4-fluorophenyl)ethyl]-4-methyl-3-pyridazinamine (1145786-63-5) + 4-methyl-1-[2-(methyloxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-imidazole (1145786-44-2) → N-[(1S)-1-(4-fluorophenyl)ethyl]-4-methyl-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-3-pyridazinamine (1145785-97-2)

Guidance literature:

With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; at 80 ℃; for 2h; Product distribution / selectivity;

Reference yield:

3-chloro-4-methyl-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]pyridazine (1145786-71-5) + (S)-1-(4-Fluoro-phenyl)-ethylamine (66399-30-2) → N-[(1S)-1-(4-fluorophenyl)ethyl]-4-methyl-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-3-pyridazinamine (1145785-97-2)

Guidance literature:

With caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; for 3h; Product distribution / selectivity; Heating / reflux;

Reference yield:

N-[(1S)-1-(4-fluorophenyl)ethyl]-4-methyl-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-3-pyridazinamine (1145785-97-2) → N-[(1S)-1-(4-fluorophenyl)ethyl]-4-methyl-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-3-pyridazinamine hydrochloride (1145785-96-1)

Guidance literature:

With hydrogenchloride; In diethyl ether; dichloromethane; Product distribution / selectivity;

upstream raw materials:

3-chloro-4-methyl-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]pyridazine

(S)-1-(4-Fluoro-phenyl)-ethylamine

[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]boronic acid

6-chloro-N-[(1S)-1-(4-fluorophenyl)ethyl]-4-methyl-3-pyridazinamine

Downstream raw materials:

N-[(1S)-1-(4-fluorophenyl)ethyl]-4-methyl-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-3-pyridazinamine hydrochloride