3-Ethoxycarbonylmethyl-2-hydroxy-6-methyl-benzoic acid ethyl ester

Base Information

• Chemical Name: 3-Ethoxycarbonylmethyl-2-hydroxy-6-methyl-benzoic acid ethyl ester
• CAS No.: 137644-90-7
• Molecular Formula: C₁₄H₁₈O₅
• Molecular Weight: 266.294
• Mol file: 137644-90-7.mol

Synonyms:3-Ethoxycarbonylmethyl-2-hydroxy-6-methyl-benzoic acid ethyl ester

Chemical Property of 3-Ethoxycarbonylmethyl-2-hydroxy-6-methyl-benzoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-Ethoxycarbonylmethyl-2-hydroxy-6-methyl-benzoic acid ethyl ester

There total 2 articles about 3-Ethoxycarbonylmethyl-2-hydroxy-6-methyl-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl 3--2-hydroxy-6-methylbenzoate (137644-87-2) → 3-Ethoxycarbonylmethyl-2-hydroxy-6-methyl-benzoic acid ethyl ester (137644-90-7)

Guidance literature:

With acetic acid; zinc; In dichloromethane;

DOI:10.1039/P19910002565

Reference yield:

ethyl 2-hydroxy-6-methylbenzoate (6555-40-4) → 3-Ethoxycarbonylmethyl-2-hydroxy-6-methyl-benzoic acid ethyl ester (137644-90-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) stannic chloride / 1) CH₂Cl₂, 15 min., 2) CCl₄, CH₂Cl₂, 1 h

2: 92 percent / Zn, glacial acetic acid / CH₂Cl₂

With tin(IV) chloride; acetic acid; zinc; In dichloromethane;

DOI:10.1039/P19910002565

Reference yield: 81.0%

3-Ethoxycarbonylmethyl-2-hydroxy-6-methyl-benzoic acid ethyl ester (137644-90-7) → ethyl 2-(2-hydroxy-3-hydroxymethyl-4-methylphenyl)acetate (137644-91-8)

Guidance literature:

With sodium tetrahydroborate; In ethyl acetate; for 7h; Heating;

DOI:10.1039/P19910002565

upstream raw materials:

ethyl 3--2-hydroxy-6-methylbenzoate

ethyl 2-hydroxy-6-methylbenzoate

Downstream raw materials:

ethyl 2-(2-hydroxy-3-hydroxymethyl-4-methylphenyl)acetate

ethyl 2-(3-formyl-2-hydroxy-4-methylphenyl)acetate