4-(3-BROMO-PHENYL)-1-N-BOC-PIPERIDINE

Base Information

• Chemical Name: 4-(3-BROMO-PHENYL)-1-N-BOC-PIPERIDINE
• CAS No.: 886362-62-5
• Molecular Formula: C16H22 Br N O2
• Molecular Weight: 340.26
• Hs Code.: 2933399090
• Mol file: 886362-62-5.mol

Synonyms:4-(3-Bromo-phenyl)-piperidine-1-;4-(3-Bromophenyl)-1-piperidinecarboxylic acid tert-butyl ester

Chemical Property of 4-(3-BROMO-PHENYL)-1-N-BOC-PIPERIDINE

Chemical Property:

• Vapor Pressure: 1.55E-06mmHg at 25°C
• Refractive Index: 1.543
• Boiling Point: 397.8°C at 760 mmHg
• PKA: -1.69±0.40(Predicted)
• Flash Point: 194.4°C
• PSA: 29.54000
• Density: 1.283
• LogP: 4.50150
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

tert-Butyl 4-(3-bromophenyl)piperidine-1-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-BROMO-PHENYL)-1-N-BOC-PIPERIDINE

There total 1 articles about 4-(3-BROMO-PHENYL)-1-N-BOC-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-(3-bromophenyl)piperidine hydrochloride (1159825-25-8) → tert-butyl-4-(3-bromophenyl)piperidine-1-carboxylate (886362-62-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.7b01255

Reference yield: 100.0%

tert-butyl-4-(3-bromophenyl)piperidine-1-carboxylate (886362-62-5) + 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine (321724-19-0) → tert-butyl 4-(3-(pyrimidin-5-yl)phenyl)piperidine-1-carboxylate

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,2-dimethoxyethane; water; at 120 ℃; for 0.75h; Sealed tube; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.ejmech.2019.05.041

Reference yield: 99.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + tert-butyl-4-(3-bromophenyl)piperidine-1-carboxylate (886362-62-5) → 4-(3-bromophenyl)-1-methylpiperidine (1187928-92-2)

Guidance literature:

formaldehyd; tert-butyl-4-(3-bromophenyl)piperidine-1-carboxylate; With formic acid; at 150 ℃; for 0.166667h; Microwave irradiation;

With ammonia; In methanol;

upstream raw materials:

di-tert-butyl dicarbonate

4-(3-bromophenyl)piperidine hydrochloride

Downstream raw materials:

4-(3-bromophenyl)-1-methylpiperidine

Refernces