(2R,4S)-4-[(1R,2R)-1-Benzyloxy-2-(4-methoxy-benzyloxy)-but-3-enyl]-2-phenyl-[1,3]dioxan-5-one

Base Information

Chemical Name:(2R,4S)-4-[(1R,2R)-1-Benzyloxy-2-(4-methoxy-benzyloxy)-but-3-enyl]-2-phenyl-[1,3]dioxan-5-one
CAS No.:168138-12-3
Molecular Formula:C₂₉H₃₀O₆
Molecular Weight:474.554
Hs Code.:

Synonyms:(2R,4S)-4-[(1R,2R)-1-Benzyloxy-2-(4-methoxy-benzyloxy)-but-3-enyl]-2-phenyl-[1,3]dioxan-5-one

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Chemical Property of (2R,4S)-4-[(1R,2R)-1-Benzyloxy-2-(4-methoxy-benzyloxy)-but-3-enyl]-2-phenyl-[1,3]dioxan-5-one

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Technology Process of (2R,4S)-4-[(1R,2R)-1-Benzyloxy-2-(4-methoxy-benzyloxy)-but-3-enyl]-2-phenyl-[1,3]dioxan-5-one

There total 10 articles about (2R,4S)-4-[(1R,2R)-1-Benzyloxy-2-(4-methoxy-benzyloxy)-but-3-enyl]-2-phenyl-[1,3]dioxan-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 168138-11-2
(1'R,2R,2'R,4R,5R)-4-<1-benzyloxy-2-(4-methoxybenzyl)oxy-3-butenyl>-5-hydroxy-2-phenyl-1,3-dioxane

: 168138-12-3
(2R,4S)-4-[(1R,2R)-1-Benzyloxy-2-(4-methoxy-benzyloxy)-but-3-enyl]-2-phenyl-[1,3]dioxan-5-one

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane;
DOI:10.1016/0040-4039(94)02458-N

Reference yield:

: 13992-16-0,23661-28-1,24404-53-3,28512-68-7,65236-85-3,86782-39-0,121524-01-4,121570-34-1,108032-93-5
phenyl 2,3,4,6-tetra-O-acetyl-1-thio-α-D-mannopyranoside

: 168138-12-3
(2R,4S)-4-[(1R,2R)-1-Benzyloxy-2-(4-methoxy-benzyloxy)-but-3-enyl]-2-phenyl-[1,3]dioxan-5-one

Guidance literature:: Multi-step reaction with 7 steps

1: NH₃ / methanol / Ambient temperature

2: HBF₄*OEt₂ / dimethylformamide / Ambient temperature

3: 1.) n-Bu₂SnO, 2.) CsF / 1.) toluene, reflux, 3 h, 2.) DMF, room temperature, 12 h

4: 94 percent / NaH / dimethylformamide; paraffin / 12 h / Ambient temperature

5: 54 percent / NBS / acetone; H₂O / 0.5 h / Ambient temperature

6: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 deg C -> room temperature

7: 2.32 g / (COCl)2, DMSO, Et₃N / CH₂Cl₂

With tetrafluoroboric acid diethyl ether; N-Bromosuccinimide; n-butyllithium; oxalyl dichloride; ammonia; sodium hydride; di(n-butyl)tin oxide; dimethyl sulfoxide; triethylamine; cesium fluoride; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone; paraffin;
DOI:10.1016/S0040-4020(97)00360-8

Reference yield:

: 2936-70-1,5624-48-6,13992-15-9,16758-34-2,28244-97-5,77481-63-1,105088-17-3,149495-84-1,77481-62-0
(2R,3S,4S,5S,6R)-2-Hydroxymethyl-6-phenylsulfanyl-tetrahydro-pyran-3,4,5-triol

: 168138-12-3
(2R,4S)-4-[(1R,2R)-1-Benzyloxy-2-(4-methoxy-benzyloxy)-but-3-enyl]-2-phenyl-[1,3]dioxan-5-one

Guidance literature:: Multi-step reaction with 6 steps

1: HBF₄*OEt₂ / dimethylformamide / Ambient temperature

2: 1.) n-Bu₂SnO, 2.) CsF / 1.) toluene, reflux, 3 h, 2.) DMF, room temperature, 12 h

3: 94 percent / NaH / dimethylformamide; paraffin / 12 h / Ambient temperature

4: 54 percent / NBS / acetone; H₂O / 0.5 h / Ambient temperature

5: 66 percent / n-BuLi / tetrahydrofuran; hexane / -78 deg C -> room temperature

6: 2.32 g / (COCl)2, DMSO, Et₃N / CH₂Cl₂

With tetrafluoroboric acid diethyl ether; N-Bromosuccinimide; n-butyllithium; oxalyl dichloride; sodium hydride; di(n-butyl)tin oxide; dimethyl sulfoxide; triethylamine; cesium fluoride; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone; paraffin;
DOI:10.1016/S0040-4020(97)00360-8