(2R,4R,5S,6S)-4,5-bis(benzyloxy)-2-((benzyloxy)methyl)-6-(4-chloro-3-(4-ethylbenzyl)phenyl)-3,3-difluorotetrahydro-2H-pyran

Base Information

Chemical Name:(2R,4R,5S,6S)-4,5-bis(benzyloxy)-2-((benzyloxy)methyl)-6-(4-chloro-3-(4-ethylbenzyl)phenyl)-3,3-difluorotetrahydro-2H-pyran
CAS No.:1181680-59-0
Molecular Formula:C₄₂H₄₁ClF₂O₄
Molecular Weight:683.235
Hs Code.:

Synonyms:(2R,4R,5S,6S)-4,5-bis(benzyloxy)-2-((benzyloxy)methyl)-6-(4-chloro-3-(4-ethylbenzyl)phenyl)-3,3-difluorotetrahydro-2H-pyran

Suppliers and Price of (2R,4R,5S,6S)-4,5-bis(benzyloxy)-2-((benzyloxy)methyl)-6-(4-chloro-3-(4-ethylbenzyl)phenyl)-3,3-difluorotetrahydro-2H-pyran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,4R,5S,6S)-4,5-bis(benzyloxy)-2-((benzyloxy)methyl)-6-(4-chloro-3-(4-ethylbenzyl)phenyl)-3,3-difluorotetrahydro-2H-pyran

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4R,5S,6S)-4,5-bis(benzyloxy)-2-((benzyloxy)methyl)-6-(4-chloro-3-(4-ethylbenzyl)phenyl)-3,3-difluorotetrahydro-2H-pyran

There total 18 articles about (2R,4R,5S,6S)-4,5-bis(benzyloxy)-2-((benzyloxy)methyl)-6-(4-chloro-3-(4-ethylbenzyl)phenyl)-3,3-difluorotetrahydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1181680-58-9
C₄₂H₄₁ClO₅

: 1181680-59-0
(2R,4R,5S,6S)-4,5-bis(benzyloxy)-2-((benzyloxy)methyl)-6-(4-chloro-3-(4-ethylbenzyl)phenyl)-3,3-difluorotetrahydro-2H-pyran

Guidance literature:: With BAST; In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: C₄₂H₄₁ClF₂O₅

: 1181680-59-0
(2R,4R,5S,6S)-4,5-bis(benzyloxy)-2-((benzyloxy)methyl)-6-(4-chloro-3-(4-ethylbenzyl)phenyl)-3,3-difluorotetrahydro-2H-pyran

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; acetonitrile; at -10 ℃; for 1h;
DOI:10.1016/j.tetlet.2012.02.062

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 1181680-59-0
(2R,4R,5S,6S)-4,5-bis(benzyloxy)-2-((benzyloxy)methyl)-6-(4-chloro-3-(4-ethylbenzyl)phenyl)-3,3-difluorotetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 20 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C

3: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 1 h / 20 °C

4: Dess-Martin periodane / dichloromethane / 3 h / 20 °C

5: BAST / dichloromethane / 20 h / 20 °C

With triethylsilane; boron trifluoride diethyl etherate; sodium hydride; Dess-Martin periodane; toluene-4-sulfonic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil;