1-(2-Methoxycarbonyl-acetyl)-5-oxo-pyrrolidine-2-carboxylic acid benzyl ester

Base Information

• Chemical Name: 1-(2-Methoxycarbonyl-acetyl)-5-oxo-pyrrolidine-2-carboxylic acid benzyl ester
• CAS No.: 196882-05-0
• Molecular Formula: C₁₆H₁₇NO₆
• Molecular Weight: 319.314
• Mol file: 196882-05-0.mol

Synonyms:1-(2-Methoxycarbonyl-acetyl)-5-oxo-pyrrolidine-2-carboxylic acid benzyl ester

Chemical Property of 1-(2-Methoxycarbonyl-acetyl)-5-oxo-pyrrolidine-2-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 1-(2-Methoxycarbonyl-acetyl)-5-oxo-pyrrolidine-2-carboxylic acid benzyl ester

There total 1 articles about 1-(2-Methoxycarbonyl-acetyl)-5-oxo-pyrrolidine-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

benzyl 5-oxopyrrolidine-2-carboxylate (60555-57-9) + 3-chloro-3-oxopropanoic acid methyl ester (37517-81-0) → 1-(2-Methoxycarbonyl-acetyl)-5-oxo-pyrrolidine-2-carboxylic acid benzyl ester (196882-05-0)

Guidance literature:

In benzene; for 6h; Heating;

DOI:10.1021/jo970625o

Reference yield: 95.0%

1-(2-Methoxycarbonyl-acetyl)-5-oxo-pyrrolidine-2-carboxylic acid benzyl ester (196882-05-0) → 1-(2-Diazo-2-methoxycarbonyl-acetyl)-5-oxo-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:

With triethylamine; Methanesulfonyl azide; In dichloromethane; for 5h; Ambient temperature;

DOI:10.1021/jo970625o

Reference yield:

1-(2-Methoxycarbonyl-acetyl)-5-oxo-pyrrolidine-2-carboxylic acid benzyl ester (196882-05-0) → tetrahydro-1,3,5-trioxo-2-phenyl-7H-4,9a-epoxy-1H-pyrrolo[3,4-g]indolizine-4,7-dicarboxylic acid 4-methyl ester 7-benzyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / mesyl azide, Et₃N / CH₂Cl₂ / 5 h / Ambient temperature

2: 12 percent / Rh₂(pfm)4 / benzene / Heating

With Rh₂(pfm)4; triethylamine; Methanesulfonyl azide; In dichloromethane; benzene;

DOI:10.1021/jo970625o

upstream raw materials:

benzyl 5-oxopyrrolidine-2-carboxylate

3-chloro-3-oxopropanoic acid methyl ester