1,7a-Diphenyl-6-p-tolyl-tetrahydro-imidazo[1,5-b][1,2,4]oxadiazol-2-one

Base Information

• Chemical Name: 1,7a-Diphenyl-6-p-tolyl-tetrahydro-imidazo[1,5-b][1,2,4]oxadiazol-2-one
• CAS No.: 190076-46-1
• Molecular Formula: C₂₃H₂₁N₃O₂
• Molecular Weight: 371.439
• Mol file: 190076-46-1.mol

Synonyms:1,7a-Diphenyl-6-p-tolyl-tetrahydro-imidazo[1,5-b][1,2,4]oxadiazol-2-one

Chemical Property of 1,7a-Diphenyl-6-p-tolyl-tetrahydro-imidazo[1,5-b][1,2,4]oxadiazol-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,7a-Diphenyl-6-p-tolyl-tetrahydro-imidazo[1,5-b][1,2,4]oxadiazol-2-one

There total 2 articles about 1,7a-Diphenyl-6-p-tolyl-tetrahydro-imidazo[1,5-b][1,2,4]oxadiazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

phenyl isocyanate (103-71-9) + 2-[(2-hydroxyimino-2-phenyl-ethyl)-p-tolyl-amino]-1-phenyl-ethanone oxime (248583-84-8) → 1,7a-Diphenyl-6-p-tolyl-tetrahydro-imidazo[1,5-b][1,2,4]oxadiazol-2-one (190076-46-1)

Guidance literature:

In acetonitrile; for 21h; Heating;

DOI:10.1080/00397919908085909

Reference yield:

p-toluidine (106-49-0,12221-03-3) → 1,7a-Diphenyl-6-p-tolyl-tetrahydro-imidazo[1,5-b][1,2,4]oxadiazol-2-one (190076-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / aq. ethanol / 6 h / 20 °C

2: 56 percent / acetonitrile / 21 h / Heating

In ethanol; acetonitrile; 1: Alkylation / 2: Beckmann fragmentation;

DOI:10.1080/00397919908085909

Reference yield: 97.0%

1,7a-Diphenyl-6-p-tolyl-tetrahydro-imidazo[1,5-b][1,2,4]oxadiazol-2-one (190076-46-1) → 4-phenyl-1-p-tolyl-2,5-dihydro-1H-imidazole 3-oxide (71906-88-2)

Guidance literature:

at 165 ℃; for 0.333333h; under 1300 Torr;

DOI:10.1016/S0040-4020(97)00876-4

upstream raw materials:

phenyl isocyanate

2-[(2-hydroxyimino-2-phenyl-ethyl)-p-tolyl-amino]-1-phenyl-ethanone oxime

p-toluidine

Downstream raw materials:

4-phenyl-1-p-tolyl-2,5-dihydro-1H-imidazole 3-oxide

4-phenyl-1-(p-tolyl)-1H-imidazole