Technology Process of 3-methyl-6-oxo-3-((trimethylsilyl)ethynyl)cyclohex-1-enecarbonitrile
There total 9 articles about 3-methyl-6-oxo-3-((trimethylsilyl)ethynyl)cyclohex-1-enecarbonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
benzene;
for 0.166667h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride; water / acetone / 5 h / 20 °C
2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.33 h / -78 - 20 °C
2.2: 0.5 h / -78 °C
3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / benzene / 0.17 h / Reflux
With
hydrogenchloride; water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide;
In
tetrahydrofuran; n-heptane; ethylbenzene; acetone; benzene;
DOI:10.1021/jm3003922
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: methyllithium / tetrahydrofuran; diethyl ether / 20 °C / Cooling with ice
1.2: 0.25 h / 20 °C / Cooling with ice
2.1: hydrogenchloride; water / acetone / 5 h / 20 °C
3.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.33 h / -78 - 20 °C
3.2: 0.5 h / -78 °C
4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / benzene / 0.17 h / Reflux
With
hydrogenchloride; water; methyllithium; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; n-heptane; ethylbenzene; acetone; benzene;
DOI:10.1021/jm3003922
