(+)-trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benzindol-5-ol mandelate

Base Information

Chemical Name:(+)-trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benzindol-5-ol mandelate
CAS No.:81206-42-0
Molecular Formula:C₂₉H₂₈N₂O₆S
Molecular Weight:532.617
Hs Code.:

(+)-trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benz<cd>indol-5-ol mandelate

Synonyms:(+)-trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benzindol-5-ol mandelate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benzindol-5-ol mandelate

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Technology Process of (+)-trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benzindol-5-ol mandelate

There total 3 articles about (+)-trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benzindol-5-ol mandelate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81206-38-4
4-azido-1-(toluene-4-sulfonyl)-3,4-dihydro-1H-benzo[c,d]indol-5-one

: 81206-42-0
(+)-trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benzindol-5-ol mandelate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10 percent Pd/C / tetrahydrofuran / 2 h / Ambient temperature

2: NaBH₄ / tetrahydrofuran; ethanol / 1 h / Ambient temperature

3: dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.5 h

With dmap; sodium tetrahydroborate; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo00132a040

Reference yield:

: 81206-39-5
4-(acetylamino)-5-acetoxy-1,3-dihydro-1-(p-tolylsulfonyl)benzindole

: 81206-42-0
(+)-trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benzindol-5-ol mandelate

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₄ / tetrahydrofuran; ethanol / 1 h / Ambient temperature

2: dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.5 h

With dmap; sodium tetrahydroborate; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo00132a040

Reference yield:

: 3966-32-3
(-)-2-methoxy-2-phenylacetic acid

: 81218-97-5
trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benzindol-5-ol

: 81206-42-0
(+)-trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benzindol-5-ol mandelate

: 81244-89-5
(-)-trans-4-(acetylamino)-1,3,4,5-tetrahydro-1-(p-tolylsulfonyl)benzindol-5-ol mandelate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 1.5h; Yield given. Yields of byproduct given;
DOI:10.1021/jo00132a040