Technology Process of (R)-tert-butyl (8-(2,6-dichlorophenyl)-2-chromanyl)methylcarbamate
There total 17 articles about (R)-tert-butyl (8-(2,6-dichlorophenyl)-2-chromanyl)methylcarbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium phosphate;
tetrakis(triphenylphosphine) palladium(0);
In
N,N-dimethyl acetamide;
at 100 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: sulfuric acid; hydrogen / 5% palladium over charcoal / 12 h / 50 °C / 2068.65 - 2585.81 Torr
2.1: sodium hydroxide; water / 0.17 h / 20 - 42 °C
2.2: pH 3
3.1: tert-butyl methyl ether; acetonitrile / 6.08 h / 20 °C / Resolution of racemate
4.1: hydrogenchloride / tert-butyl methyl ether; water / 0.17 h / 20 °C
5.1: thionyl chloride / toluene / 18 h / 65 °C
6.1: ammonia / tetrahydrofuran; water; toluene / 18 h / 0 - 5 °C
7.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / -5 - 20 °C
7.2: -25 - 20 °C
8.1: dichloromethane / 0 - 20 °C
9.1: tert.-butyl lithium / tetrahydrofuran; pentane / 18.83 h / -60 - -57 °C
9.2: -70 - 20 °C
9.3: 2 h / -5 - 20 °C
10.1: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl acetamide / 18 h / 100 °C
With
hydrogenchloride; sodium hydroxide; potassium phosphate; thionyl chloride; sulfuric acid; ammonia; water; hydrogen; tert.-butyl lithium; sodium bis(2-methoxyethoxy)aluminium dihydride;
tetrakis(triphenylphosphine) palladium(0); 5% palladium over charcoal;
In
tetrahydrofuran; dichloromethane; tert-butyl methyl ether; N,N-dimethyl acetamide; water; toluene; acetonitrile; pentane;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium hydroxide; water / 0.17 h / 20 - 42 °C
1.2: pH 3
2.1: tert-butyl methyl ether; acetonitrile / 6.08 h / 20 °C / Resolution of racemate
3.1: hydrogenchloride / tert-butyl methyl ether; water / 0.17 h / 20 °C
4.1: thionyl chloride / toluene / 18 h / 65 °C
5.1: ammonia / tetrahydrofuran; water; toluene / 18 h / 0 - 5 °C
6.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / -5 - 20 °C
6.2: -25 - 20 °C
7.1: dichloromethane / 0 - 20 °C
8.1: tert.-butyl lithium / tetrahydrofuran; pentane / 18.83 h / -60 - -57 °C
8.2: -70 - 20 °C
8.3: 2 h / -5 - 20 °C
9.1: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl acetamide / 18 h / 100 °C
With
hydrogenchloride; sodium hydroxide; potassium phosphate; thionyl chloride; ammonia; water; tert.-butyl lithium; sodium bis(2-methoxyethoxy)aluminium dihydride;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dichloromethane; tert-butyl methyl ether; N,N-dimethyl acetamide; water; toluene; acetonitrile; pentane;
