5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-pyrrolidin-1-yl-propoxy)-benzyl]-1H-indole

Base Information

• Chemical Name: 5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-pyrrolidin-1-yl-propoxy)-benzyl]-1H-indole
• CAS No.: 869006-49-5
• Molecular Formula: C₄₃H₄₄N₂O₃
• Molecular Weight: 636.834

Synonyms:5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-pyrrolidin-1-yl-propoxy)-benzyl]-1H-indole

Chemical Property of 5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-pyrrolidin-1-yl-propoxy)-benzyl]-1H-indole

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Technology Process of 5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-pyrrolidin-1-yl-propoxy)-benzyl]-1H-indole

There total 2 articles about 5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-pyrrolidin-1-yl-propoxy)-benzyl]-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1-[(S)-2-(4-Chloromethyl-phenoxy)-1-methyl-ethyl]-pyrrolidine (869006-43-9) + 5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1H-indole (198479-63-9) → 5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-pyrrolidin-1-yl-propoxy)-benzyl]-1H-indole (869006-49-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2005.08.084

Reference yield:

[4-((S)-2-Pyrrolidin-1-yl-propoxy)-phenyl]-methanol; hydrochloride → 5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-pyrrolidin-1-yl-propoxy)-benzyl]-1H-indole (869006-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / tetrahydrofuran

2: 67 percent / NaH / dimethylformamide

With thionyl chloride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2005.08.084

Reference yield: 70.0%

5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-pyrrolidin-1-yl-propoxy)-benzyl]-1H-indole (869006-49-5) → 2-(4-hydroxy-phenyl)-3-methyl-1-[4-(2-pyrrolidin-1-yl-propoxy)-benzyl]-1H-indol-5-ol

Guidance literature:

With ammonium formate; palladium; In ethanol; ethyl acetate;

DOI:10.1016/j.bmcl.2005.08.084

upstream raw materials:

1-[(S)-2-(4-Chloromethyl-phenoxy)-1-methyl-ethyl]-pyrrolidine

5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1H-indole

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