(1R-trans)-1-methyl-4-(1-methylethyl)-2-cyclohexene-1-acetonitrile

Base Information

• Chemical Name: (1R-trans)-1-methyl-4-(1-methylethyl)-2-cyclohexene-1-acetonitrile
• CAS No.: 131251-89-3
• Molecular Formula: C₁₂H₁₉N
• Molecular Weight: 177.29
• Mol file: 131251-89-3.mol

Synonyms:(1R-trans)-1-methyl-4-(1-methylethyl)-2-cyclohexene-1-acetonitrile

Chemical Property of (1R-trans)-1-methyl-4-(1-methylethyl)-2-cyclohexene-1-acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R-trans)-1-methyl-4-(1-methylethyl)-2-cyclohexene-1-acetonitrile

There total 5 articles about (1R-trans)-1-methyl-4-(1-methylethyl)-2-cyclohexene-1-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

<1R-(1α,2β,4β,7α)>-N-(3,3,7-trimethyltricyclo<5.2.0.02,4>nonan-9-yliden)-benzenesulfenamide (131251-82-6) → (1R-trans)-1-methyl-4-(1-methylethyl)-2-cyclohexene-1-acetonitrile (131251-89-3)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In cyclohexane; Heating;

DOI:10.1021/ja00003a057

Reference yield: 6.0%

<1R-(1α,2β,4β,7α)>-N-(3,3,7-trimethyltricyclo<5.2.0.02,4>nonan-9-yliden)-benzenesulfenamide (131251-82-6) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → (1R-trans)-1-methyl-4-(1-methylethyl)-2-cyclohexene-1-acetonitrile (131251-89-3) + (3aS,6S,7aR)-6-Cyanomethyl-3,3,6-trimethyl-octahydro-indene-1-carboxylic acid methyl ester (131251-94-0,131251-95-1)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In cyclohexane; Heating;

DOI:10.1021/ja00003a057

Reference yield:

<1R-(1α,2β,4β,7α)>-3,3,7-trimethyltricyclo<5.2.0.02,4>nonan-9-one (156963-24-5) → (1R-trans)-1-methyl-4-(1-methylethyl)-2-cyclohexene-1-acetonitrile (131251-89-3)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; toluene-4-sulfonic acid; 1H-1,2,3-benzotriazol-1-amine; Yield given. Multistep reaction; 1.) toluene, 2.) reflux, 2 h;

DOI:10.1021/jo952173q

upstream raw materials:

<1R-(1α,2β,4β,7α)>-N-(3,3,7-trimethyltricyclo<5.2.0.0^2,4>nonan-9-yliden)-benzenesulfenamide

acrylic acid methyl ester

<1R-(1α,2β,4β,7α)>-3,3,7-trimethyltricyclo<5.2.0.0^2,4>nonan-9-one

Δ²-(+)-carene