2-bromo-1-(5-(difluoromethoxy)-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazole

Base Information

• Chemical Name: 2-bromo-1-(5-(difluoromethoxy)-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazole
• CAS No.: 1226805-68-0
• Molecular Formula: C₁₂H₁₀BrF₂N₃O₄
• Molecular Weight: 378.13

Synonyms:2-bromo-1-(5-(difluoromethoxy)-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazole

Chemical Property of 2-bromo-1-(5-(difluoromethoxy)-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazole

Chemical Property:

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Technology Process of 2-bromo-1-(5-(difluoromethoxy)-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazole

There total 1 articles about 2-bromo-1-(5-(difluoromethoxy)-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-bromo-4-methyl-1H-imidazol-1-yl)-5-methoxy-4-nitrophenol (1226805-67-9) + sodium chlorodifluoroacetate (1895-39-2) → 2-bromo-1-(5-(difluoromethoxy)-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazole (1226805-68-0)

Guidance literature:

With potassium carbonate; In water; N,N-dimethyl-formamide; at 80 - 110 ℃;

Reference yield:

5-methoxy-3-pyridinylboronic acid (850991-69-4) + 2-bromo-1-(5-(difluoromethoxy)-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazole (1226805-68-0) → 3-(1-(5-(difluoromethoxy)-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazol-2-yl)-5-methoxypyridine (1226805-69-1)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 110 ℃; for 16h;

upstream raw materials:

3-(2-bromo-4-methyl-1H-imidazol-1-yl)-5-methoxy-4-nitrophenol

sodium chlorodifluoroacetate

Downstream raw materials:

3-(1-(5-(difluoromethoxy)-3-methoxy-2-nitrophenyl)-4-methyl-1H-imidazol-2-yl)-5-methoxypyridine

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