(1R,2S,3S,4R)-1-Hydroxymethyl-3-methoxy-2-((E)-1-methyl-penta-1,4-dienyl)-cyclohexane-1,4-diol

Base Information

Chemical Name:(1R,2S,3S,4R)-1-Hydroxymethyl-3-methoxy-2-((E)-1-methyl-penta-1,4-dienyl)-cyclohexane-1,4-diol
CAS No.:192931-92-3
Molecular Formula:C₁₄H₂₄O₄
Molecular Weight:256.342
Hs Code.:

Synonyms:(1R,2S,3S,4R)-1-Hydroxymethyl-3-methoxy-2-((E)-1-methyl-penta-1,4-dienyl)-cyclohexane-1,4-diol

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Chemical Property of (1R,2S,3S,4R)-1-Hydroxymethyl-3-methoxy-2-((E)-1-methyl-penta-1,4-dienyl)-cyclohexane-1,4-diol

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Technology Process of (1R,2S,3S,4R)-1-Hydroxymethyl-3-methoxy-2-((E)-1-methyl-penta-1,4-dienyl)-cyclohexane-1,4-diol

There total 2 articles about (1R,2S,3S,4R)-1-Hydroxymethyl-3-methoxy-2-((E)-1-methyl-penta-1,4-dienyl)-cyclohexane-1,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 192932-02-8
[(1R,2S,3S,4R)-1,4-Bis-benzyloxy-3-methoxy-2-((E)-1-methyl-penta-1,4-dienyl)-cyclohexyl]-methanol

: 192931-92-3
(1R,2S,3S,4R)-1-Hydroxymethyl-3-methoxy-2-((E)-1-methyl-penta-1,4-dienyl)-cyclohexane-1,4-diol

Guidance literature:: With ammonia; lithium; at -78 ℃; for 0.0333333h;
DOI:10.1016/S0040-4039(97)00925-8

Reference yield:

: 192931-83-2
(1R,2S,3S,4R)-1,4-Bis-benzyloxy-3-methoxy-2-((E)-1-methyl-penta-1,4-dienyl)-cyclohexanecarboxylic acid methyl ester

: 192931-92-3
(1R,2S,3S,4R)-1-Hydroxymethyl-3-methoxy-2-((E)-1-methyl-penta-1,4-dienyl)-cyclohexane-1,4-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / DIBALH / toluene / 0.67 h / -78 °C

2: 90 percent / lithium, NH₃ / 0.03 h / -78 °C

With ammonia; lithium; diisobutylaluminium hydride; In toluene;
DOI:10.1016/S0040-4039(97)00925-8

Reference yield:

: 192931-92-3
(1R,2S,3S,4R)-1-Hydroxymethyl-3-methoxy-2-((E)-1-methyl-penta-1,4-dienyl)-cyclohexane-1,4-diol

: 35903-52-7,128656-25-7,132746-73-7,108102-51-8
fumagillol

Guidance literature:: Multi-step reaction with 5 steps

1: TEA, DMAP / CH₂Cl₂ / 12 h / Ambient temperature

2: K₂CO₃ / methanol / 4 h / Ambient temperature

3: 84 percent / m-CPBA, NaHCO₃ / CH₂Cl₂ / 4 h / 0 °C

4: ozone / ethyl acetate / 0.02 h / -78 °C

5: tetrahydrofuran / 2 h / -78 - 20 °C

With dmap; TEA; sodium hydrogencarbonate; potassium carbonate; ozone; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4039(97)00925-8