Technology Process of C12H14FNO4
There total 1 articles about C12H14FNO4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium tert-butylate;
In
1-methyl-pyrrolidin-2-one;
at -20 - -10 ℃;
for 0.5h;
Inert atmosphere;
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
for 2h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: hydrogen; palladium 10% on activated carbon / methanol / 2 h
2: sodium nitrite; toluene-4-sulfonic acid; potassium iodide / water; acetonitrile / 10 - 20 °C
3: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); zinc; dimethyl amine / 15 h / 120 °C / Inert atmosphere
4: hydrogenchloride / 1,4-dioxane / 18 h / 25 °C
5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 23 °C / Cooling with ice
6: ethanol; sodium hydroxide / 4 h / 80 °C
7: thionyl chloride / 4.5 h / 0 - 40 °C / Cooling with ice
With
hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); thionyl chloride; ethanol; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dimethyl amine; triethylamine; potassium iodide; sodium hydroxide; zinc; sodium nitrite;
In
1,4-dioxane; methanol; dichloromethane; water; acetonitrile;
