N-[(2R,3R,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-(pyridin-2-ylsulfanyl)-tetrahydro-pyran-3-yl]-acetamide

Base Information

Chemical Name:N-[(2R,3R,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-(pyridin-2-ylsulfanyl)-tetrahydro-pyran-3-yl]-acetamide
CAS No.:182355-74-4
Molecular Formula:C₃₄H₃₆N₂O₅S
Molecular Weight:584.736
Hs Code.:

Synonyms:N-[(2R,3R,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-(pyridin-2-ylsulfanyl)-tetrahydro-pyran-3-yl]-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(2R,3R,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-(pyridin-2-ylsulfanyl)-tetrahydro-pyran-3-yl]-acetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[(2R,3R,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-(pyridin-2-ylsulfanyl)-tetrahydro-pyran-3-yl]-acetamide

There total 5 articles about N-[(2R,3R,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-(pyridin-2-ylsulfanyl)-tetrahydro-pyran-3-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2127-03-9
2,2'-dipyridyldisulphide

: 182355-74-4
N-[(2R,3R,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-(pyridin-2-ylsulfanyl)-tetrahydro-pyran-3-yl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 614 mg / tributylphosphine / CH₂Cl₂ / 1 h / 20 °C

2: SnCl₂, thiophenol, triethylamine / acetonitrile / 0.33 h / 20 °C / other reagents: triphenylphosphine, NiCl₂/NaBH₄, SmI₂

3: 703 mg / pyridine

With pyridine; tributylphosphine; thiophenol; triethylamine; tin(ll) chloride; In dichloromethane; acetonitrile;
DOI:10.1021/jo971727h

Reference yield:

: 2-((3R,4R,5R,6R)-3-Azido-4,5-bis-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-ylsulfanyl)-pyridine

: 182355-74-4
N-[(2R,3R,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-(pyridin-2-ylsulfanyl)-tetrahydro-pyran-3-yl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: SnCl₂, PhSH, Et₃N / acetonitrile

2: pyridine

With pyridine; thiophenol; triethylamine; tin(ll) chloride; In acetonitrile;
DOI:10.1039/CC9960001883

Reference yield:

: 2637-34-5,73018-10-7
2-Sulfanylpyridine

: 182355-74-4
N-[(2R,3R,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-(pyridin-2-ylsulfanyl)-tetrahydro-pyran-3-yl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.61 g / BF₃*Et₂O / CH₂Cl₂ / 1 h / -15 °C / other reagent: trimethylsilyl triflate

2: SnCl₂, thiophenol, triethylamine / acetonitrile / 0.33 h / 20 °C / other reagents: triphenylphosphine, NiCl₂/NaBH₄, SmI₂

3: 703 mg / pyridine

With pyridine; boron trifluoride diethyl etherate; thiophenol; triethylamine; tin(ll) chloride; In dichloromethane; acetonitrile;
DOI:10.1021/jo971727h