1H-Pyrrolizine-1-carboxaldehyde, hexahydro-5-oxo-, cis- (9CI)

Base Information

Chemical Name:1H-Pyrrolizine-1-carboxaldehyde, hexahydro-5-oxo-, cis- (9CI)
CAS No.:89556-97-8
Molecular Formula:C₈H₁₁NO₂
Molecular Weight:153.181
Hs Code.:
Mol file:89556-97-8.mol

Synonyms:1H-Pyrrolizine-1-carboxaldehyde,hexahydro-5-oxo-, cis- (9CI); 1H-Pyrrolizine-1-carboxaldehyde, hexahydro-5-oxo-,cis-(?à)-

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrrolizine-1-carboxaldehyde, hexahydro-5-oxo-, cis- (9CI)

Chemical Property:

PSA：37.38000
LogP:0.13410

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolizine-1-carboxaldehyde, hexahydro-5-oxo-, cis- (9CI)

There total 10 articles about 1H-Pyrrolizine-1-carboxaldehyde, hexahydro-5-oxo-, cis- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 89556-96-7
1-Aza-4-(1,3-dithian-2-yl)bicyclo<3.3.0>octan-8-one

: 89556-97-8
(+/-)-(5β)-6β-formyl-1-azabicyclo<3.3.0>octan-2-one

Guidance literature:: With calcium carbonate; mercury dichloride; In water; acetonitrile; at 25 ℃;
DOI:10.1021/jo00184a002

Reference yield:

: 83177-76-8
1-(3-[1,3]Dithian-2-ylidene-propyl)-5-hydroxy-pyrrolidin-2-one

: 89556-97-8
(+/-)-(5β)-6β-formyl-1-azabicyclo<3.3.0>octan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: methanesulfonyl chloride, triethylamine / CH₂Cl₂ / -20 deg C to r.t.

2: 71 percent / CF₃SO₃H, (C₂H₅)3SiH / CH₂Cl₂ / 25 °C

3: 67 percent / HgCl₂, CaCO₃ / acetonitrile; H₂O / 25 °C

With triethylsilane; trifluorormethanesulfonic acid; methanesulfonyl chloride; triethylamine; calcium carbonate; mercury dichloride; In dichloromethane; water; acetonitrile;
DOI:10.1021/jo00184a002

Reference yield:

: 83177-75-7
N-(3-(1,3-Dithian-2-ylidene)propyl)-2,5-pyrrolidinedione

: 89556-97-8
(+/-)-(5β)-6β-formyl-1-azabicyclo<3.3.0>octan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄ / methanol / 1 h / -4 °C

2: methanesulfonyl chloride, triethylamine / CH₂Cl₂ / -20 deg C to r.t.

3: 71 percent / CF₃SO₃H, (C₂H₅)3SiH / CH₂Cl₂ / 25 °C

4: 67 percent / HgCl₂, CaCO₃ / acetonitrile; H₂O / 25 °C

With triethylsilane; sodium tetrahydroborate; trifluorormethanesulfonic acid; methanesulfonyl chloride; triethylamine; calcium carbonate; mercury dichloride; In methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo00184a002