(2R,5S)-3-benzoyl-2-(tert-butyl)-4-(<1-(tert-butyloxycarbonyl)-1H-indol-3-yl>methyl)-4-methyl-5-oxazolidinon

Base Information

Chemical Name:(2R,5S)-3-benzoyl-2-(tert-butyl)-4-(<1-(tert-butyloxycarbonyl)-1H-indol-3-yl>methyl)-4-methyl-5-oxazolidinon
CAS No.:116139-85-6
Molecular Formula:C₂₉H₃₄N₂O₅
Molecular Weight:490.599
Hs Code.:

Synonyms:(2R,5S)-3-benzoyl-2-(tert-butyl)-4-(<1-(tert-butyloxycarbonyl)-1H-indol-3-yl>methyl)-4-methyl-5-oxazolidinon

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Chemical Property of (2R,5S)-3-benzoyl-2-(tert-butyl)-4-(<1-(tert-butyloxycarbonyl)-1H-indol-3-yl>methyl)-4-methyl-5-oxazolidinon

Chemical Property:

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Technology Process of (2R,5S)-3-benzoyl-2-(tert-butyl)-4-(<1-(tert-butyloxycarbonyl)-1H-indol-3-yl>methyl)-4-methyl-5-oxazolidinon

There total 1 articles about (2R,5S)-3-benzoyl-2-(tert-butyl)-4-(<1-(tert-butyloxycarbonyl)-1H-indol-3-yl>methyl)-4-methyl-5-oxazolidinon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96551-21-2
1-(t-butyloxycarbonyl)-3-(bromomethyl)indole

: 104057-65-0
(2R,4S)-3-benzoyl-2-(tert-butyl)-4-methyl-1,3-oxazolidin-5-one

: 116139-85-6
(2R,5S)-3-benzoyl-2-(tert-butyl)-4-(<1-(tert-butyloxycarbonyl)-1H-indol-3-yl>methyl)-4-methyl-5-oxazolidinon

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -78 deg C, 40 min, 2.) THF, -78 deg C, 36 h;
DOI:10.1002/hlca.19880710124

Reference yield: 59.0%

: 116139-85-6
(2R,5S)-3-benzoyl-2-(tert-butyl)-4-(<1-(tert-butyloxycarbonyl)-1H-indol-3-yl>methyl)-4-methyl-5-oxazolidinon

: 116139-87-8
(S)-N²-benzoyl-2-methyltryptophan-methylester

Guidance literature:: With sodium methylate; In methanol; for 24h; Ambient temperature;
DOI:10.1002/hlca.19880710124

Reference yield:

: 116139-85-6
(2R,5S)-3-benzoyl-2-(tert-butyl)-4-(<1-(tert-butyloxycarbonyl)-1H-indol-3-yl>methyl)-4-methyl-5-oxazolidinon

: 16709-25-4,13510-08-2
(S)-α-methyltryptophan

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / 1N MeONa / methanol / 24 h / Ambient temperature

2: 87 percent / 6N HCl / methanol / Heating

With hydrogenchloride; sodium methylate; In methanol;
DOI:10.1002/hlca.19880710124