Technology Process of (2S,3S,4R)-1-boc-4-hydroxy-3-methylproline
There total 1 articles about (2S,3S,4R)-1-boc-4-hydroxy-3-methylproline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 1H-imidazole / dichloromethane / 0 °C
2.1: sode de l'acide trichloroisocyanurique / toluene; water / 0 °C
3.1: triethylamine / toluene / 1 h / 0 - 20 °C
4.1: 2,6-dimethylpyridine / dichloromethane / -10 - 40 °C
5.1: copper(I) bromide dimethylsulfide complex / diethyl ether / 0.75 h / -50 - -25 °C / Inert atmosphere
5.2: 0.75 h / -50 - -40 °C
6.1: hydrogen / palladium 10% on activated carbon / methanol / -50 - -25 °C / 2068.65 Torr
7.1: tert-butylhypochlorite / diethyl ether / 0.33 h / 0 °C
8.1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 5 h / -40 - 20 °C
9.1: sodium carbonate / water / 1.25 h / 20 °C
10.1: lithium hydroxide / water; methanol / 20 °C
10.2: pH 2
With
1H-imidazole; 2,6-dimethylpyridine; copper(I) bromide dimethylsulfide complex; tert-butylhypochlorite; hydrogen; sodium tris(acetoxy)borohydride; sode de l'acide trichloroisocyanurique; sodium carbonate; acetic acid; triethylamine; lithium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; toluene;
- Guidance literature:
-
(2S,3S,4R)-1-boc-4-hydroxy-3-methylproline;
With
potassium tert-butylate;
In
dimethyl sulfoxide;
at 20 ℃;
for 0.25h;
2-(2-chloro-1-isopropyl-1H-benzo[d]imidazol-4-yl)-4-cyclohexylthiazole;
In
dimethyl sulfoxide;
for 2h;
