Technology Process of 2-methyl-5-m-tolyl-oxazole-4-carbonyl chloride
There total 5 articles about 2-methyl-5-m-tolyl-oxazole-4-carbonyl chloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
oxalyl dichloride;
In
dichloromethane;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium nitrite; acetic acid / water / 2.25 h / 10 - 20 °C / Inert atmosphere
2.1: sodium acetate; acetic acid / mercury dichloride / water / 1 h / Reflux
3.1: thionyl chloride / chloroform / 2.5 h / 0 °C / Reflux; Inert atmosphere
4.1: sodium hydroxide; water / tetrahydrofuran / 3 h
4.2: pH 3 - 4 / Cooling with ice
5.1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 1 h / 20 °C / Inert atmosphere
With
thionyl chloride; oxalyl dichloride; water; sodium acetate; acetic acid; sodium hydroxide; sodium nitrite;
N,N-dimethyl-formamide; mercury dichloride;
In
tetrahydrofuran; chloroform; water; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium acetate; acetic acid / mercury dichloride / water / 1 h / Reflux
2.1: thionyl chloride / chloroform / 2.5 h / 0 °C / Reflux; Inert atmosphere
3.1: sodium hydroxide; water / tetrahydrofuran / 3 h
3.2: pH 3 - 4 / Cooling with ice
4.1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 1 h / 20 °C / Inert atmosphere
With
thionyl chloride; oxalyl dichloride; water; sodium acetate; acetic acid; sodium hydroxide;
N,N-dimethyl-formamide; mercury dichloride;
In
tetrahydrofuran; chloroform; water; toluene;
