N-(2,3-difluorophenyl)-2-(4-{[(dimethylamino)methylene]amino}-1H-pyrazol-1-yl)acetamide

Base Information

• Chemical Name: N-(2,3-difluorophenyl)-2-(4-{[(dimethylamino)methylene]amino}-1H-pyrazol-1-yl)acetamide
• CAS No.: 930779-55-8
• Molecular Formula: C₁₄H₁₅F₂N₅O
• Molecular Weight: 307.303
• Mol file: 930779-55-8.mol

Synonyms:N-(2,3-difluorophenyl)-2-(4-{[(dimethylamino)methylene]amino}-1H-pyrazol-1-yl)acetamide

Chemical Property of N-(2,3-difluorophenyl)-2-(4-{[(dimethylamino)methylene]amino}-1H-pyrazol-1-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2,3-difluorophenyl)-2-(4-{[(dimethylamino)methylene]amino}-1H-pyrazol-1-yl)acetamide

There total 3 articles about N-(2,3-difluorophenyl)-2-(4-{[(dimethylamino)methylene]amino}-1H-pyrazol-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

2-bromo-N-(2,3-difluorophenyl)acetamide (804550-60-5) + N,N-dimethyl-N'-1H-pyrazol-4-ylimidoformamide (930779-56-9) → N-(2,3-difluorophenyl)-2-(4-{[(dimethylamino)methylene]amino}-1H-pyrazol-1-yl)acetamide (930779-55-8)

Guidance literature:

N,N-dimethyl-N'-1H-pyrazol-4-ylimidoformamide; With sodium hydride; In 1,4-dioxane; N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

2-bromo-N-(2,3-difluorophenyl)acetamide; In 1,4-dioxane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield:

N-[3-(dimethylamino)-2-{[(dimethylamino)methylene]amino}prop-2-en-1-ylidene]-N-methylmethanaminium hydrogen monohexafluorophosphate + {2-[(2,3-difluorophenyl)amino]-2-oxoethyl}hydrazinium dimethanesulfonate → N-(2,3-difluorophenyl)-2-(4-{[(dimethylamino)methylene]amino}-1H-pyrazol-1-yl)acetamide (930779-55-8) + N-(2,3-difluorophenyl)-2-[4-(formylamino)-1H-pyrazol-1-yl]acetamide

Guidance literature:

N-[3-(dimethylamino)-2-{[(dimethylamino)methylene]amino}prop-2-en-1-ylidene]-N-methylmethanaminium hydrogen monohexafluorophosphate; {2-[(2,3-difluorophenyl)amino]-2-oxoethyl}hydrazinium dimethanesulfonate; With pyridine; In methanol; at -30 - -15 ℃;

With sodium methylate; In pyridine; methanol; at -30 - 60 ℃; for 1.33333h;

With potassium hydrogencarbonate; In water; pH=7 - 8;

Reference yield:

N-[3-(dimethylamino)-2-{[(dimethylamino)methylene]amino}prop-2-en-1-ylidene]-N-methylmethanaminium hydrogen monohexafluorophosphate + {2-[(2,3-difluorophenyl)amino]-2-oxoethyl}hydrazinium dimethanesulfonate → N-(2,3-difluorophenyl)-2-(4-{[(dimethylamino)methylene]amino}-1H-pyrazol-1-yl)acetamide (930779-55-8) + 2-(4-amino-1H-pyrazol-1-yl)-N-(2,3-difluorophenyl)acetamide (786681-68-3)

Guidance literature:

N-[3-(dimethylamino)-2-{[(dimethylamino)methylene]amino}prop-2-en-1-ylidene]-N-methylmethanaminium hydrogen monohexafluorophosphate; {2-[(2,3-difluorophenyl)amino]-2-oxoethyl}hydrazinium dimethanesulfonate; In pyridine; methanol; at -30 - -15 ℃; for 0.0833333h;

With sodium methylate; In pyridine; methanol; at 20 - 60 ℃; for 1.25h; Further stages.;

DOI:10.1055/s-2007-966054

upstream raw materials:

2-bromo-N-(2,3-difluorophenyl)acetamide

N,N-dimethyl-N'-1H-pyrazol-4-ylimidoformamide

Downstream raw materials:

2-(4-amino-1H-pyrazol-1-yl)-N-(2,3-difluorophenyl)acetamide