(R)-(3-oxo-3,6-dihydro[1,2]oxazin-2-yl)-phenylacetic acid benzhydryl ester

Base Information

Chemical Name:(R)-(3-oxo-3,6-dihydro[1,2]oxazin-2-yl)-phenylacetic acid benzhydryl ester
CAS No.:494870-84-7
Molecular Formula:C₂₇H₂₅NO₄
Molecular Weight:427.5
Hs Code.:

Synonyms:(R)-(3-oxo-3,6-dihydro[1,2]oxazin-2-yl)-phenylacetic acid benzhydryl ester

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Chemical Property of (R)-(3-oxo-3,6-dihydro[1,2]oxazin-2-yl)-phenylacetic acid benzhydryl ester

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Technology Process of (R)-(3-oxo-3,6-dihydro[1,2]oxazin-2-yl)-phenylacetic acid benzhydryl ester

There total 4 articles about (R)-(3-oxo-3,6-dihydro[1,2]oxazin-2-yl)-phenylacetic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 494870-83-6
(R)-α-allyloxyaminophenylacetic acid benzhydryl ester

: 814-68-6,25189-84-8
acryloyl chloride

: 494870-84-7
(R)-(3-oxo-3,6-dihydro[1,2]oxazin-2-yl)-phenylacetic acid benzhydryl ester

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1139/v04-174

Reference yield:

: 17199-29-0
(S)-Mandelic acid

: 494870-84-7
(R)-(3-oxo-3,6-dihydro[1,2]oxazin-2-yl)-phenylacetic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / ethyl acetate / 1 h / 20 °C

2.1: triflic anhydride; 2,6-lutidine / CH₂Cl₂ / 1 h / -68 °C

2.2: CH₂Cl₂ / 17 h / 20 °C

3.1: 81 percent / 2,6-lutidine / CH₂Cl₂ / 0 - 20 °C

With 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride; In dichloromethane; ethyl acetate;
DOI:10.1139/v04-174

Reference yield:

: 908093-98-1
diazodiphenylmethane

: 494870-84-7
(R)-(3-oxo-3,6-dihydro[1,2]oxazin-2-yl)-phenylacetic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / ethyl acetate / 1 h / 20 °C

2.1: triflic anhydride; 2,6-lutidine / CH₂Cl₂ / 1 h / -68 °C

2.2: CH₂Cl₂ / 17 h / 20 °C

3.1: 81 percent / 2,6-lutidine / CH₂Cl₂ / 0 - 20 °C

With 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride; In dichloromethane; ethyl acetate;
DOI:10.1139/v04-174