(5S,1'R)-5-<<3'-<(1-methyl-1H-imidazol-4-yl)methyl>-5'-oxocyclohex-3'-en-1'-yl>methyl>-1-(phenylmethyl)pyrrolidin-2-one

Base Information

Chemical Name:(5S,1'R)-5-<<3'-<(1-methyl-1H-imidazol-4-yl)methyl>-5'-oxocyclohex-3'-en-1'-yl>methyl>-1-(phenylmethyl)pyrrolidin-2-one
CAS No.:157718-91-7
Molecular Formula:C₂₃H₂₇N₃O₂
Molecular Weight:377.486
Hs Code.:

Synonyms:(5S,1'R)-5-<<3'-<(1-methyl-1H-imidazol-4-yl)methyl>-5'-oxocyclohex-3'-en-1'-yl>methyl>-1-(phenylmethyl)pyrrolidin-2-one

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Chemical Property of (5S,1'R)-5-<<3'-<(1-methyl-1H-imidazol-4-yl)methyl>-5'-oxocyclohex-3'-en-1'-yl>methyl>-1-(phenylmethyl)pyrrolidin-2-one

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Technology Process of (5S,1'R)-5-<<3'-<(1-methyl-1H-imidazol-4-yl)methyl>-5'-oxocyclohex-3'-en-1'-yl>methyl>-1-(phenylmethyl)pyrrolidin-2-one

There total 2 articles about (5S,1'R)-5-<<3'-<(1-methyl-1H-imidazol-4-yl)methyl>-5'-oxocyclohex-3'-en-1'-yl>methyl>-1-(phenylmethyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 131879-92-0
(5S,1'S)-5-<(3'-ethoxy-5'-oxocyclohex-3'-en-1'-yl)methyl>-1-(phenylmethyl)pyrrolidin-2-one

: 157718-91-7
(5S,1'R)-5-<<3'-<(1-methyl-1H-imidazol-4-yl)methyl>-5'-oxocyclohex-3'-en-1'-yl>methyl>-1-(phenylmethyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / CrCl₃*7H₂O, NaBH₄ / methanol / 1 h / 0 °C

2: 2.) BuLi, 3.) 6N HCl / 1.) THF, RT, 1.5 h, 2.) THF, hexane, -78 deg C, 45 min, 3.) H₂O, RT, 1 h

With hydrogenchloride; chromium chloride; sodium tetrahydroborate; n-butyllithium; In methanol;
DOI:10.1002/hlca.19940770207

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 603-35-0
triphenylphosphine

: 157718-89-3
(5S,1'R)-5-<(5'-oxocyclohex-3'-en-1'-yl)methyl>-1-(phenylmethyl)pyrrolidin-2-one

: 17289-26-8
1-methyl-1H-imidazole-4-carbaldehyde

: 157718-91-7
(5S,1'R)-5-<<3'-<(1-methyl-1H-imidazol-4-yl)methyl>-5'-oxocyclohex-3'-en-1'-yl>methyl>-1-(phenylmethyl)pyrrolidin-2-one

Guidance literature:: With hydrogenchloride; n-butyllithium; Yield given. Multistep reaction; 1.) THF, RT, 1.5 h, 2.) THF, hexane, -78 deg C, 45 min, 3.) H₂O, RT, 1 h;
DOI:10.1002/hlca.19940770207

Reference yield: 90.0%

: 157718-91-7
(5S,1'R)-5-<<3'-<(1-methyl-1H-imidazol-4-yl)methyl>-5'-oxocyclohex-3'-en-1'-yl>methyl>-1-(phenylmethyl)pyrrolidin-2-one

: 157718-94-0
(5S,1'R,5'S)-5-<<3'-oxo-5'-<(1-methyl-1H-imidazol-4-yl)methyl>cyclohex-1'-yl>methyl>-1-(phenylethyl)-pyrrolidin-2-one

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 2h; under 2068.6 Torr;
DOI:10.1002/hlca.19940770207