phenacyl 4-<(L-prolyloxy)methyl>benzoate hydrochloride

Base Information

• Chemical Name: phenacyl 4-<(L-prolyloxy)methyl>benzoate hydrochloride
• CAS No.: 136631-87-3
• Molecular Formula: C₂₁H₂₁NO₅*ClH
• Molecular Weight: 403.862
• Mol file: 136631-87-3.mol

Synonyms:phenacyl 4-<(L-prolyloxy)methyl>benzoate hydrochloride

Chemical Property of phenacyl 4-<(L-prolyloxy)methyl>benzoate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenacyl 4-<(L-prolyloxy)methyl>benzoate hydrochloride

There total 5 articles about phenacyl 4-<(L-prolyloxy)methyl>benzoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.7%

phenacyl 4-<<<(tert-butoxycarbonyl)-L-prolyl>oxy>methyl>benzoate (136631-86-2) → phenacyl 4-<(L-prolyloxy)methyl>benzoate hydrochloride (136631-87-3)

Guidance literature:

With trifluoroacetic acid; for 3h;

DOI:10.1021/jo00023a035

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) → phenacyl 4-<(L-prolyloxy)methyl>benzoate hydrochloride (136631-87-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / 4-(dimethylamino)pyridine, dicyclohexylcarbodiimide / CH₂Cl₂ / 1) 0 deg C, 2 h, 2) r.t., 18 h

2: 99.7 percent / trifluoroacetic acid / 3 h

With dmap; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jo00023a035

Reference yield:

3-hydroxymethyl-benzoic acid (3006-96-0) → phenacyl 4-<(L-prolyloxy)methyl>benzoate hydrochloride (136631-87-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / Et₃N / ethyl acetate / 64 h

2: 100 percent / 4-(dimethylamino)pyridine, dicyclohexylcarbodiimide / CH₂Cl₂ / 1) 0 deg C, 2 h, 2) r.t., 18 h

3: 99.7 percent / trifluoroacetic acid / 3 h

With dmap; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; ethyl acetate;

DOI:10.1021/jo00023a035

upstream raw materials:

phenacyl 4-<<<(tert-butoxycarbonyl)-L-prolyl>oxy>methyl>benzoate

1-(tert-butoxycarbonyl)-L-proline

3-hydroxymethyl-benzoic acid

phenacyl 4-(hydroxymethyl)benzoate

Downstream raw materials:

4-<<α-(tert-butoxycarbonyl)-N^ε-(9-fluorenylmethoxycarbonyl)-L-lysyl-L-prolyl>oxy>methyl>benzoic acid

phenacyl 4-<<α-(tert-butoxycarbonyl)-N^ε-(9-fluorenylmethoxycarbonyl)-L-lysyl-L-prolyl>oxy>methyl>benzoate