1-(2-chlorophenyl)-3-(4-methoxyphenyl)-2-thia-3-azabicyclo[3.1.0]hexane 2,2-dioxide

Base Information

Chemical Name:1-(2-chlorophenyl)-3-(4-methoxyphenyl)-2-thia-3-azabicyclo[3.1.0]hexane 2,2-dioxide
CAS No.:1417156-41-2
Molecular Formula:C₁₇H₁₆ClNO₃S
Molecular Weight:349.838
Hs Code.:

Synonyms:1-(2-chlorophenyl)-3-(4-methoxyphenyl)-2-thia-3-azabicyclo[3.1.0]hexane 2,2-dioxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-chlorophenyl)-3-(4-methoxyphenyl)-2-thia-3-azabicyclo[3.1.0]hexane 2,2-dioxide

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Technology Process of 1-(2-chlorophenyl)-3-(4-methoxyphenyl)-2-thia-3-azabicyclo[3.1.0]hexane 2,2-dioxide

There total 6 articles about 1-(2-chlorophenyl)-3-(4-methoxyphenyl)-2-thia-3-azabicyclo[3.1.0]hexane 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₁₈Br₂ClNO₃S

: 1417156-41-2
1-(2-chlorophenyl)-3-(4-methoxyphenyl)-2-thia-3-azabicyclo[3.1.0]hexane 2,2-dioxide

Guidance literature:: With sodium hydride; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 0.5h;
DOI:10.1002/ejoc.201200670

Reference yield:

: 41345-36-2
Sodium 2-chlorobenzylsulphonate

: 1417156-41-2
1-(2-chlorophenyl)-3-(4-methoxyphenyl)-2-thia-3-azabicyclo[3.1.0]hexane 2,2-dioxide

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / N,N-dimethyl-formamide / 5 - 20 °C

2: 4-methyl-morpholine / dichloromethane / 10 - 30 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

4: bromine / dichloromethane / 0.67 h / 0 °C

5: sodium hydride / dimethyl sulfoxide; mineral oil / 0.5 h / 20 °C

With 4-methyl-morpholine; thionyl chloride; bromine; sodium hydride; potassium carbonate; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/ejoc.201200670

Reference yield:

: 611-19-8
1-chloro-2-(chloromethyl)benzene

: 1417156-41-2
1-(2-chlorophenyl)-3-(4-methoxyphenyl)-2-thia-3-azabicyclo[3.1.0]hexane 2,2-dioxide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium sulphite-heptahydrate; tetrabutylammomium bromide / water / 6 h / 80 °C

2: thionyl chloride / N,N-dimethyl-formamide / 5 - 20 °C

3: 4-methyl-morpholine / dichloromethane / 10 - 30 °C

4: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

5: bromine / dichloromethane / 0.67 h / 0 °C

6: sodium hydride / dimethyl sulfoxide; mineral oil / 0.5 h / 20 °C

With 4-methyl-morpholine; thionyl chloride; sodium sulphite-heptahydrate; tetrabutylammomium bromide; bromine; sodium hydride; potassium carbonate; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/ejoc.201200670