trans-3-amino-1-cyclopropyl-3-(4-(10-fluoro-3-phenyl-5H-benzo[e]imidazo[1,2-c][1,3]oxazin-2-yl)phenyl)cyclobutanol

Base Information

Chemical Name:trans-3-amino-1-cyclopropyl-3-(4-(10-fluoro-3-phenyl-5H-benzo[e]imidazo[1,2-c][1,3]oxazin-2-yl)phenyl)cyclobutanol
CAS No.:1402602-63-4
Molecular Formula:C₂₉H₂₆FN₃O₂
Molecular Weight:467.543
Hs Code.:

Synonyms:trans-3-amino-1-cyclopropyl-3-(4-(10-fluoro-3-phenyl-5H-benzo[e]imidazo[1,2-c][1,3]oxazin-2-yl)phenyl)cyclobutanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of trans-3-amino-1-cyclopropyl-3-(4-(10-fluoro-3-phenyl-5H-benzo[e]imidazo[1,2-c][1,3]oxazin-2-yl)phenyl)cyclobutanol

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Technology Process of trans-3-amino-1-cyclopropyl-3-(4-(10-fluoro-3-phenyl-5H-benzo[e]imidazo[1,2-c][1,3]oxazin-2-yl)phenyl)cyclobutanol

There total 17 articles about trans-3-amino-1-cyclopropyl-3-(4-(10-fluoro-3-phenyl-5H-benzo[e]imidazo[1,2-c][1,3]oxazin-2-yl)phenyl)cyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402603-99-9
C₃₇H₂₈FN₃O₄

: 1402602-63-4
trans-3-amino-1-cyclopropyl-3-(4-(10-fluoro-3-phenyl-5H-benzo[e]imidazo[1,2-c][1,3]oxazin-2-yl)phenyl)cyclobutanol

Guidance literature:: With hydrazine hydrate; In ethanol; at 110 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 1402602-63-4
trans-3-amino-1-cyclopropyl-3-(4-(10-fluoro-3-phenyl-5H-benzo[e]imidazo[1,2-c][1,3]oxazin-2-yl)phenyl)cyclobutanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

1.2: 3 h / 20 - 26 °C

1.3: 20 °C / Heating

2.1: sulfuric acid / 20 °C / Reflux

3.1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / chloroform / 24 h / 20 °C / Cooling with ice

4.1: tetrahydrofuran; toluene / 3.25 h / -40 - 0 °C

4.2: 20 °C

4.3: 4 h / 20 - 63 °C

5.1: triethylamine / chloroform / 38 h / 70 °C

6.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

7.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

8.1: hydrazine hydrate / ethanol / 0.33 h / 110 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrapropylammonium perruthennate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; isopropylmagnesium chloride; potassium acetate; caesium carbonate; hydrazine hydrate; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; chloroform; water; toluene;

Reference yield:

: 1402603-95-5
trans-3-amino-3-(4-bromophenyl)-1-cyclopropylcyclobutanol

: 1402602-63-4
trans-3-amino-1-cyclopropyl-3-(4-(10-fluoro-3-phenyl-5H-benzo[e]imidazo[1,2-c][1,3]oxazin-2-yl)phenyl)cyclobutanol

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / chloroform / 38 h / 70 °C

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

4: hydrazine hydrate / ethanol / 0.33 h / 110 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; caesium carbonate; hydrazine hydrate; triethylamine; In 1,4-dioxane; ethanol; chloroform; water;