N4-[2-(5-chloro-2-fluoro-phenyl)-quinolin-4-yl]-pyridine-3,4-diamine

Base Information

Chemical Name:N*4*-[2-(5-chloro-2-fluoro-phenyl)-quinolin-4-yl]-pyridine-3,4-diamine
CAS No.:1303556-79-7
Molecular Formula:C₂₀H₁₄ClFN₄
Molecular Weight:364.809
Hs Code.:

Synonyms:N*4*-[2-(5-chloro-2-fluoro-phenyl)-quinolin-4-yl]-pyridine-3,4-diamine

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Chemical Property of N*4*-[2-(5-chloro-2-fluoro-phenyl)-quinolin-4-yl]-pyridine-3,4-diamine

Chemical Property:

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Technology Process of N*4*-[2-(5-chloro-2-fluoro-phenyl)-quinolin-4-yl]-pyridine-3,4-diamine

There total 6 articles about N*4*-[2-(5-chloro-2-fluoro-phenyl)-quinolin-4-yl]-pyridine-3,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1303556-78-6
[2-(5-chloro-2-fluoro-phenyl)-quinolin-4-yl]-(3-nitro-pyridin-4-yl)-amine

: 1303556-79-7
N*4*-[2-(5-chloro-2-fluoro-phenyl)-quinolin-4-yl]-pyridine-3,4-diamine

Guidance literature:: With hydrogen; In tetrahydrofuran;

Reference yield:

: 1303557-96-1
4-bromo-2-(5-chloro-2-fluoro-phenyl)-quinoline

: 1303556-79-7
N*4*-[2-(5-chloro-2-fluoro-phenyl)-quinolin-4-yl]-pyridine-3,4-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-Amyl alcohol / 6.5 h / 100 - 117 °C / Inert atmosphere

2: hydrogen / tetrahydrofuran

With potassium phosphate; 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; hydrogen; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; tert-Amyl alcohol;

Reference yield:

: 1019367-42-0
N-(2-acetyl-phenyl)-5-chloro-2-fluoro-benzamide

: 1303556-79-7
N*4*-[2-(5-chloro-2-fluoro-phenyl)-quinolin-4-yl]-pyridine-3,4-diamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tert-butyl alcohol / 20 h / 75 °C

1.2: pH 1 - 2 / Cooling with ice

2.1: phosphorus(V) oxybromide / 1-methyl-pyrrolidin-2-one / 4.5 h / 20 - 95 °C

3.1: potassium phosphate; 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tert-Amyl alcohol / 6.5 h / 100 - 117 °C / Inert atmosphere

4.1: hydrogen / tetrahydrofuran

With potassium phosphate; 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; potassium tert-butylate; hydrogen; phosphorus(V) oxybromide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; tert-Amyl alcohol; tert-butyl alcohol;