(2,4-bis-benzyloxy-5-isopropenylphenyl)-(5-bromo-1,3-dihydroisoindol-2-yl)methanone

Base Information

Chemical Name:(2,4-bis-benzyloxy-5-isopropenylphenyl)-(5-bromo-1,3-dihydroisoindol-2-yl)methanone
CAS No.:913000-21-2
Molecular Formula:C₃₂H₂₈BrNO₃
Molecular Weight:554.483
Hs Code.:

Synonyms:(2,4-bis-benzyloxy-5-isopropenylphenyl)-(5-bromo-1,3-dihydroisoindol-2-yl)methanone

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Chemical Property of (2,4-bis-benzyloxy-5-isopropenylphenyl)-(5-bromo-1,3-dihydroisoindol-2-yl)methanone

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Technology Process of (2,4-bis-benzyloxy-5-isopropenylphenyl)-(5-bromo-1,3-dihydroisoindol-2-yl)methanone

There total 7 articles about (2,4-bis-benzyloxy-5-isopropenylphenyl)-(5-bromo-1,3-dihydroisoindol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 912545-09-6
2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)benzoic acid

: 127168-84-7
5-bromoisoindoline

: 913000-21-2
(2,4-bis-benzyloxy-5-isopropenylphenyl)-(5-bromo-1,3-dihydroisoindol-2-yl)methanone

Guidance literature:: With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 25 ℃; for 13h; Reagent/catalyst; Solvent;
DOI:10.1080/00397911.2019.1602654

Reference yield:

: 912545-15-4
benzyl 2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)benzoate

: 913000-21-2
(2,4-bis-benzyloxy-5-isopropenylphenyl)-(5-bromo-1,3-dihydroisoindol-2-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran; methanol / 6 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; dmap / dichloromethane / 13 h / 0 - 25 °C

With dmap; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1080/00397911.2019.1602654

Reference yield:

: 89-86-1
4-hydroxysalicylic acid

: 913000-21-2
(2,4-bis-benzyloxy-5-isopropenylphenyl)-(5-bromo-1,3-dihydroisoindol-2-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 5 h / 70 °C

2: N-Bromosuccinimide / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

3: XPhos; caesium carbonate; palladium diacetate / tetrahydrofuran; water / 8 h / 90 °C / Sealed tube

4: water; lithium hydroxide / tetrahydrofuran; methanol / 6 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; dmap / dichloromethane / 13 h / 0 - 25 °C

With dmap; N-Bromosuccinimide; water; palladium diacetate; potassium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; XPhos; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1080/00397911.2019.1602654