(1R)-1-(naphthalen-1-yl)-N-((4-(3-(trifluoromethyl)benzyl)morpholin-3-yl)methyl)ethanamine

Base Information

Chemical Name:(1R)-1-(naphthalen-1-yl)-N-((4-(3-(trifluoromethyl)benzyl)morpholin-3-yl)methyl)ethanamine
CAS No.:1398241-09-2
Molecular Formula:C₂₅H₂₇F₃N₂O
Molecular Weight:428.497
Hs Code.:

Synonyms:(1R)-1-(naphthalen-1-yl)-N-((4-(3-(trifluoromethyl)benzyl)morpholin-3-yl)methyl)ethanamine

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Chemical Property of (1R)-1-(naphthalen-1-yl)-N-((4-(3-(trifluoromethyl)benzyl)morpholin-3-yl)methyl)ethanamine

Chemical Property:

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Technology Process of (1R)-1-(naphthalen-1-yl)-N-((4-(3-(trifluoromethyl)benzyl)morpholin-3-yl)methyl)ethanamine

There total 5 articles about (1R)-1-(naphthalen-1-yl)-N-((4-(3-(trifluoromethyl)benzyl)morpholin-3-yl)methyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1398396-78-5
N-((R)-1-(naphthalen-1-yl)ethyl)-4-(3-(trifluoromethyl)benzyl)morpholine-3-carboxamide

: 1398241-18-3
(1R)-1-(naphthalen-1-yl)-N-((4-(3-(trifluoromethyl)benzyl)morpholin-3-yl)methyl)ethanamine

: 1398241-09-2
(1R)-1-(naphthalen-1-yl)-N-((4-(3-(trifluoromethyl)benzyl)morpholin-3-yl)methyl)ethanamine

Guidance literature:: N-((R)-1-(naphthalen-1-yl)ethyl)-4-(3-(trifluoromethyl)benzyl)morpholine-3-carboxamide; With dimethylsulfide borane complex; In tetrahydrofuran; for 6h; Reflux;

With hydrogenchloride; In water; at 100 ℃; for 1h;

With sodium hydroxide; In water; pH=10;

Reference yield:

: 473923-56-7
tert-Butyl 3-(hydroxymethyl)-4-morpholinecarboxylate

: 1398241-18-3
(1R)-1-(naphthalen-1-yl)-N-((4-(3-(trifluoromethyl)benzyl)morpholin-3-yl)methyl)ethanamine

: 1398241-09-2
(1R)-1-(naphthalen-1-yl)-N-((4-(3-(trifluoromethyl)benzyl)morpholin-3-yl)methyl)ethanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate; trichloroisocyanuric acid; sodium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / water; acetone / 0 - 20 °C

2.1: diisopropyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 0.25 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 3 h / 0 °C

4.1: potassium carbonate / toluene / 20 h / 110 °C

5.1: dimethylsulfide borane complex / tetrahydrofuran / 6 h / Reflux

5.2: 1 h / 100 °C

5.3: pH 10

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; dimethylsulfide borane complex; trichloroisocyanuric acid; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; trifluoroacetic acid; sodium bromide; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; water; acetone; toluene;

Reference yield:

: 1398394-57-4
tert-butyl 3-(((R)-1-(naphthalen-1-yl)ethyl)carbamoyl)morpholine-4-carboxylate

: 1398241-18-3
(1R)-1-(naphthalen-1-yl)-N-((4-(3-(trifluoromethyl)benzyl)morpholin-3-yl)methyl)ethanamine

: 1398241-09-2
(1R)-1-(naphthalen-1-yl)-N-((4-(3-(trifluoromethyl)benzyl)morpholin-3-yl)methyl)ethanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 3 h / 0 °C

2.1: potassium carbonate / toluene / 20 h / 110 °C

3.1: dimethylsulfide borane complex / tetrahydrofuran / 6 h / Reflux

3.2: 1 h / 100 °C

3.3: pH 10

With dimethylsulfide borane complex; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;