(R)-1-[1,3-dioxo-2-(tetrahydropyran-4-ylmethyl)-2,3-dihydro-1H-isoindol-4-yl]piperidine-3-carboxylic acid 2-methoxybenzylamide

Base Information

Chemical Name:(R)-1-[1,3-dioxo-2-(tetrahydropyran-4-ylmethyl)-2,3-dihydro-1H-isoindol-4-yl]piperidine-3-carboxylic acid 2-methoxybenzylamide
CAS No.:1381925-01-4
Molecular Formula:C₂₈H₃₃N₃O₅
Molecular Weight:491.587
Hs Code.:

Synonyms:(R)-1-[1,3-dioxo-2-(tetrahydropyran-4-ylmethyl)-2,3-dihydro-1H-isoindol-4-yl]piperidine-3-carboxylic acid 2-methoxybenzylamide

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Chemical Property of (R)-1-[1,3-dioxo-2-(tetrahydropyran-4-ylmethyl)-2,3-dihydro-1H-isoindol-4-yl]piperidine-3-carboxylic acid 2-methoxybenzylamide

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Technology Process of (R)-1-[1,3-dioxo-2-(tetrahydropyran-4-ylmethyl)-2,3-dihydro-1H-isoindol-4-yl]piperidine-3-carboxylic acid 2-methoxybenzylamide

There total 3 articles about (R)-1-[1,3-dioxo-2-(tetrahydropyran-4-ylmethyl)-2,3-dihydro-1H-isoindol-4-yl]piperidine-3-carboxylic acid 2-methoxybenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1381925-22-9
(R)-piperidine-3-carboxylic acid 2-methoxy-benzylamide

: 1381925-23-0
4-fluoro-2-(tetrahydro-pyran-4-ylmethyl)-isoindole-1,3-dione

: 1381925-01-4
(R)-1-[1,3-dioxo-2-(tetrahydropyran-4-ylmethyl)-2,3-dihydro-1H-isoindol-4-yl]piperidine-3-carboxylic acid 2-methoxybenzylamide

Guidance literature:: With caesium carbonate; In dimethyl sulfoxide; at 100 ℃; for 3h;

Reference yield:

: 498-95-3,25137-00-2,59045-82-8,60252-41-7,262853-93-0
(R)-nipecotic acid

: 1381925-01-4
(R)-1-[1,3-dioxo-2-(tetrahydropyran-4-ylmethyl)-2,3-dihydro-1H-isoindol-4-yl]piperidine-3-carboxylic acid 2-methoxybenzylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; di-tert-butyl dicarbonate / chloroform / 1 h / 60 °C

1.2: 20 °C

2.1: caesium carbonate / dimethyl sulfoxide / 3 h / 100 °C

With di-tert-butyl dicarbonate; caesium carbonate; triethylamine; In chloroform; dimethyl sulfoxide;

Reference yield:

: 130290-79-8
4-tetrahydropyranmethylamine

: 652-39-1
3-fluorophthalic anhydride

: 1381925-01-4
(R)-1-[1,3-dioxo-2-(tetrahydropyran-4-ylmethyl)-2,3-dihydro-1H-isoindol-4-yl]piperidine-3-carboxylic acid 2-methoxybenzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 4 h / Reflux

2: caesium carbonate / dimethyl sulfoxide / 3 h / 100 °C

With caesium carbonate; acetic acid; In dimethyl sulfoxide;