Technology Process of eremophila-9(10),11(12)-diene-3β-ol phenylthionocarbonate
There total 6 articles about eremophila-9(10),11(12)-diene-3β-ol phenylthionocarbonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 100 percent / pyridine / 16 h / 20 °C
2.1: 72 percent / NH3; Li / tetrahydrofuran / 0.83 h / -78 °C
3.1: (COCl)2; DMSO; Et3N / CH2Cl2 / 0.33 h / -78 - 20 °C
4.1: KOH / methanol / 2 h / 20 °C
5.1: 22 mg / LiAlH4 / diethyl ether / 0.67 h / -78 °C
6.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -42 °C
6.2: tetrahydrofuran; hexane / 0.5 h / 20 °C
With
pyridine; potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; ammonia; lithium; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane;
3.1: Swern oxidation;
DOI:10.1021/jo049058c
- Guidance literature:
-
eremophila-9(10),11(12)-diene-3β-ol;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -42 ℃;
for 0.333333h;
phenylcarbonochloridothioate;
In
tetrahydrofuran; hexane;
at 20 ℃;
for 0.5h;
DOI:10.1021/jo049058c
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 72 percent / NH3; Li / tetrahydrofuran / 0.83 h / -78 °C
2.1: (COCl)2; DMSO; Et3N / CH2Cl2 / 0.33 h / -78 - 20 °C
3.1: KOH / methanol / 2 h / 20 °C
4.1: 22 mg / LiAlH4 / diethyl ether / 0.67 h / -78 °C
5.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -42 °C
5.2: tetrahydrofuran; hexane / 0.5 h / 20 °C
With
potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; ammonia; lithium; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane;
2.1: Swern oxidation;
DOI:10.1021/jo049058c
