1-{4-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-phenyl}-cyclopropanecarbonitrile

Base Information

Chemical Name:1-{4-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-phenyl}-cyclopropanecarbonitrile
CAS No.:1454654-57-9
Molecular Formula:C₁₉H₁₆N₈
Molecular Weight:356.39
Hs Code.:

Synonyms:1-{4-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-phenyl}-cyclopropanecarbonitrile

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Chemical Property of 1-{4-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-phenyl}-cyclopropanecarbonitrile

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Technology Process of 1-{4-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-phenyl}-cyclopropanecarbonitrile

There total 2 articles about 1-{4-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-phenyl}-cyclopropanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454653-99-6
5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamine

: 64399-27-5
1-(4-chlorophenyl)-1-cyclopropanecarbonitrile

: 1454654-57-9
1-{4-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-phenyl}-cyclopropanecarbonitrile

Guidance literature:: With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); lithium hexamethyldisilazane; In tert-butyl alcohol;

Reference yield:

: 1454654-39-7
6-(1-methyl-1H-pyrazol-4-yl)-pyrazin-2-ylamine

: 1454654-57-9
1-{4-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-2-ylamino]-phenyl}-cyclopropanecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 12 h / 50 °C

1.2: 3 h / 80 °C

2.1: lithium hexamethyldisilazane; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II) / tert-butyl alcohol

With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); lithium hexamethyldisilazane; In tetrahydrofuran; tert-butyl alcohol; 2.1: |Buchwald-Hartwig Coupling;