(7-(N-(2-((tert-butyldimethylsilyl)oxy)ethyl)sulfamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Base Information

Chemical Name:(7-(N-(2-((tert-butyldimethylsilyl)oxy)ethyl)sulfamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate
CAS No.:1363480-82-3
Molecular Formula:C₄₀H₄₈N₄O₁₂S₂Si
Molecular Weight:869.058
Hs Code.:

(7-(N-(2-((tert-butyldimethylsilyl)oxy)ethyl)sulfamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Synonyms:(7-(N-(2-((tert-butyldimethylsilyl)oxy)ethyl)sulfamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

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Chemical Property of (7-(N-(2-((tert-butyldimethylsilyl)oxy)ethyl)sulfamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

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Technology Process of (7-(N-(2-((tert-butyldimethylsilyl)oxy)ethyl)sulfamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

There total 15 articles about (7-(N-(2-((tert-butyldimethylsilyl)oxy)ethyl)sulfamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1363480-74-3
N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(hydroxymethyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indole-7-sulfonamide

: 1939-99-7
benzenesulfonyl chloride

: 1363480-82-3
(7-(N-(2-((tert-butyldimethylsilyl)oxy)ethyl)sulfamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: With pyridine; at 0 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm201717y

Reference yield:

: 885226-91-5
1-(1-(chloromethyl)-1H-benzo[e]indol-3(2H)-yl)-2,2,2-trifluoroethanone

: 1363480-82-3
(7-(N-(2-((tert-butyldimethylsilyl)oxy)ethyl)sulfamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: Multi-step reaction with 10 steps

1: sodium iodide / butanone / 17 h / 85 °C

2: acetonitrile / 24 h / Darkness

3: acetic acid / 48 h / Darkness

4: chlorosulfonic acid / dichloromethane / -80 - 5 °C

5: oxalyl dichloride / N,N-dimethyl-formamide / 3 h / -10 - 5 °C

6: sulfuric acid; potassium nitrate / 0.25 h / -12 °C

7: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 °C

8: water; caesium carbonate / methanol / 2.5 h / 0 - 20 °C

9: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 3.5 h

10: pyridine / 2 h / 0 °C / Inert atmosphere

With pyridine; chlorosulfonic acid; oxalyl dichloride; sulfuric acid; water; caesium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; N-ethyl-N,N-diisopropylamine; sodium iodide; In methanol; dichloromethane; N,N-dimethyl acetamide; acetic acid; N,N-dimethyl-formamide; acetonitrile; butanone;
DOI:10.1021/jm201717y

Reference yield:

: 1214876-51-3
2,2,2-trifluoro-1-(1-(iodomethyl)-1,2-dihydro-3H-benzo[e]indol-3-yl)ethan-1-one

: 1363480-82-3
(7-(N-(2-((tert-butyldimethylsilyl)oxy)ethyl)sulfamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: Multi-step reaction with 8 steps

1: 18-crown-6 ether / acetic acid / 120 h / 100 °C

2: chlorosulfonic acid / dichloromethane / -80 - 5 °C

3: oxalyl dichloride / N,N-dimethyl-formamide / 3 h / -10 - 5 °C

4: sulfuric acid; potassium nitrate / 0.25 h / -12 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 °C

6: water; caesium carbonate / methanol / 2.5 h / 0 - 20 °C

7: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 3.5 h

8: pyridine / 2 h / 0 °C / Inert atmosphere

With pyridine; chlorosulfonic acid; oxalyl dichloride; 18-crown-6 ether; sulfuric acid; water; caesium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl acetamide; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm201717y