(E)-ethyl 2-cyano-2-(3-((E)-2-(5-(2,4-dihexyl-1,2-dimethyl-1,2,3,4-tetrahydroquinolin-6-yl)thiophen-2-yl)vinyl)-5,5-dimethylcyclohex-2-enylidene)acetate

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Chemical Name:(E)-ethyl 2-cyano-2-(3-((E)-2-(5-(2,4-dihexyl-1,2-dimethyl-1,2,3,4-tetrahydroquinolin-6-yl)thiophen-2-yl)vinyl)-5,5-dimethylcyclohex-2-enylidene)acetate
CAS No.:1353003-66-3
Molecular Formula:C₄₂H₅₈N₂O₂S
Molecular Weight:655.001
Hs Code.:

Synonyms:(E)-ethyl 2-cyano-2-(3-((E)-2-(5-(2,4-dihexyl-1,2-dimethyl-1,2,3,4-tetrahydroquinolin-6-yl)thiophen-2-yl)vinyl)-5,5-dimethylcyclohex-2-enylidene)acetate

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Chemical Property of (E)-ethyl 2-cyano-2-(3-((E)-2-(5-(2,4-dihexyl-1,2-dimethyl-1,2,3,4-tetrahydroquinolin-6-yl)thiophen-2-yl)vinyl)-5,5-dimethylcyclohex-2-enylidene)acetate

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Technology Process of (E)-ethyl 2-cyano-2-(3-((E)-2-(5-(2,4-dihexyl-1,2-dimethyl-1,2,3,4-tetrahydroquinolin-6-yl)thiophen-2-yl)vinyl)-5,5-dimethylcyclohex-2-enylidene)acetate

There total 10 articles about (E)-ethyl 2-cyano-2-(3-((E)-2-(5-(2,4-dihexyl-1,2-dimethyl-1,2,3,4-tetrahydroquinolin-6-yl)thiophen-2-yl)vinyl)-5,5-dimethylcyclohex-2-enylidene)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1353003-65-2
5-(2,4-dihexyl-1,2-dimethyl-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carbaldehyde

: 78814-23-0
(E)-ethyl 2-cyano-2-(3,5,5-trimethylcyclohex-2-en-1-ylidene)acetate

: 1353003-66-3
(E)-ethyl 2-cyano-2-(3-((E)-2-(5-(2,4-dihexyl-1,2-dimethyl-1,2,3,4-tetrahydroquinolin-6-yl)thiophen-2-yl)vinyl)-5,5-dimethylcyclohex-2-enylidene)acetate

Guidance literature:: With piperidine; In acetonitrile; for 12h; Reflux; Inert atmosphere;
DOI:10.1016/j.tet.2011.11.004

Reference yield:

: 1353003-58-3
2,4-dihexyl-2-methyl-1,2,3,4-tetrahydroquinoline

: 1353003-66-3
(E)-ethyl 2-cyano-2-(3-((E)-2-(5-(2,4-dihexyl-1,2-dimethyl-1,2,3,4-tetrahydroquinolin-6-yl)thiophen-2-yl)vinyl)-5,5-dimethylcyclohex-2-enylidene)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzene / Reflux

1.2: 1 h / 70 °C

2.1: N-Bromosuccinimide / tetrachloromethane / 2 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 8 h / Reflux; Inert atmosphere

4.1: trichlorophosphate / 6 h / 55 °C / Inert atmosphere

4.2: pH 6 / Cooling with ice

5.1: piperidine / acetonitrile / 12 h / Reflux; Inert atmosphere

With piperidine; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; trichlorophosphate; In tetrachloromethane; 1,2-dimethoxyethane; water; acetonitrile; benzene; 3.1: Suzuki coupling;
DOI:10.1016/j.tet.2011.11.004

Reference yield:

: 78-59-1
3,5,5-Trimethylcyclohex-2-en-1-one

: 1353003-66-3
(E)-ethyl 2-cyano-2-(3-((E)-2-(5-(2,4-dihexyl-1,2-dimethyl-1,2,3,4-tetrahydroquinolin-6-yl)thiophen-2-yl)vinyl)-5,5-dimethylcyclohex-2-enylidene)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate; acetic acid

2: piperidine / acetonitrile / 12 h / Reflux; Inert atmosphere

With piperidine; ammonium acetate; acetic acid; In acetonitrile; 1: Knoevenagel condensation;
DOI:10.1016/j.tet.2011.11.004