(1R,3aR,4S,7aR)-7a-methyl-1-((R)-6-methyl-6-((triethylsilyl)oxy)heptan-2-yl)octahydro-1H-inden-4-ol

Base Information

• Chemical Name: (1R,3aR,4S,7aR)-7a-methyl-1-((R)-6-methyl-6-((triethylsilyl)oxy)heptan-2-yl)octahydro-1H-inden-4-ol
• CAS No.: 145223-33-2
• Molecular Formula: C₂₄H₄₈O₂Si
• Molecular Weight: 396.729

Synonyms:(1R,3aR,4S,7aR)-7a-methyl-1-((R)-6-methyl-6-((triethylsilyl)oxy)heptan-2-yl)octahydro-1H-inden-4-ol

Chemical Property of (1R,3aR,4S,7aR)-7a-methyl-1-((R)-6-methyl-6-((triethylsilyl)oxy)heptan-2-yl)octahydro-1H-inden-4-ol

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Technology Process of (1R,3aR,4S,7aR)-7a-methyl-1-((R)-6-methyl-6-((triethylsilyl)oxy)heptan-2-yl)octahydro-1H-inden-4-ol

There total 1 articles about (1R,3aR,4S,7aR)-7a-methyl-1-((R)-6-methyl-6-((triethylsilyl)oxy)heptan-2-yl)octahydro-1H-inden-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-[(S)-1-((1R,3aR,4S,7aR)-4-Hydroxy-7a-methyl-octahydro-inden-1-yl)-ethyl]-5-methyl-5-triethylsilanyloxy-hexanenitrile (145223-32-1) → de-A,B-25-hydroxycholestan-8β-ol (66774-84-3) + (1R,3aR,4S,7aR)-7a-methyl-1-((R)-6-methyl-6-((triethylsilyl)oxy)heptan-2-yl)octahydro-1H-inden-4-ol (145223-33-2)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; tert-butyl alcohol; In diethyl ether; Ambient temperature;

DOI:10.1016/S0040-4039(00)61019-5

Reference yield: 99.0%

(1R,3aR,4S,7aR)-7a-methyl-1-((R)-6-methyl-6-((triethylsilyl)oxy)heptan-2-yl)octahydro-1H-inden-4-ol (145223-33-2) → 25-[(triethylsilyl)oxy]de-A,B-cholestan-8-one (144848-24-8)

Guidance literature:

With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

3-(methoxymethoxy)benzoic acid (81245-43-4) + (1R,3aR,4S,7aR)-7a-methyl-1-((R)-6-methyl-6-((triethylsilyl)oxy)heptan-2-yl)octahydro-1H-inden-4-ol (145223-33-2) → C27H42O5

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1016/j.ejmech.2018.11.028

upstream raw materials:

2-[(S)-1-((1R,3aR,4S,7aR)-4-Hydroxy-7a-methyl-octahydro-inden-1-yl)-ethyl]-5-methyl-5-triethylsilanyloxy-hexanenitrile

Downstream raw materials:

25-[(triethylsilyl)oxy]de-A,B-cholestan-8-one

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